裘五四

◆ 导师基本情况

博士，副教授，硕士生导师

邮箱：shihai954@163.com

指导专业：外科学

◆ 研究领域

1.神经损伤、脑血管疾病、神经肿瘤的微创手术治疗

2.危急重症疾病的基础和临床

◆ 主讲课程

外科学

◆ 教育和工作经历

学习经历：

1998.09～2001.07      温州医科大学医学学士

2002.07～2007.08      浙江大学医学院硕博

工作经历：

1994.07～2002.08      杭州医学高等专科学校实验师

2007.8～              杭州师范大学医学院讲师

2007.08～             杭州师范大学附属医院神经外科医师

◆ 学术简介

目前为浙江省医学会神经外科分会青年委员会委员、浙江省中西医结合协会神经外科分会委员、杭州医学会神经外科分会秘书及委员。研究方向为重型颅脑损伤、神经肿瘤与脑血管病的微创手术治疗，特别对亚低温脑保护的临床基础、创伤评分、神经监护有专长。承担省级等科研课题17项，获省市级科研奖6项，发表医学论文42篇（其中第一或通讯作者SCI论文13篇），入选杭州市“131 第二层次人才”，任AMS,Clinical Neurology and Neurosurgery, Critical Care等杂志审稿专家，曾应邀赴国外参加国际专业会议上讲座10次。2006年参与编写《神经外科危急重症诊治指南》 。2016年共同主编《神经系统疾病危重症诊疗与监护》， 共同副主编《实用神经外科重症监护重点与难点》、2019年共同副主编《Structure and Function of DTI-based White Matter Fiber Bundles》。获得杭州市131人才等多项荣誉。Archives of Medical Science, World Journal of Pediatrics, Clinical Neurology and Neurosurgery, Critical Care，Journal of Critical Care, World Journal of Gastroenterology, Journal of Anesthesialogy and Clinical Science(JACS)等杂志审稿人。

多次国际交流( Invited Speaker)：

1.ESICM EuroAsia 2017

2.the NABIS North American Brain Injury Society's Tenth Annual Conference on Brain Injury, September 12-15, 2012, Miami, Florida.

3.International Conference on Integrated Preventive Cardiology, November 24-27, 2011. Mumbai, India

4.the 3rd International Hypothermia Symposium, September 2-5 2009, Lund, Sweden.

5.the 2nd Therapeutic Temperature Management Conference,October, 2008,Barcelona, Spain

6.the 2nd International Multidisciplinary Intensive Care Congress, Mexico City, August 28 -31, 2007.

◆ 主持教学科研项目

1.人可溶性TRAIL的基因克隆及其靶向治疗胶质瘤干细胞的实验研究 浙江省省自然基金 Y2080913

2.选择性亚低温治疗大鼠脑外伤后Fas/Fas-L基因表达的影响 杭州市卫生局2006B017

3.大骨瓣减压术联合选择性亚低温治疗脑外伤的实验研究 杭州市市卫生局2007A011

4.人可溶性TRAIL的基因克隆及其靶向治疗胶质瘤干细胞的实验研究     杭州市卫生局 2008A010

5.亚低温治疗对重型颅骨损伤患者大脑半球Pbto2梯度的影响 杭州市卫生局2010A013

6.院前亚低温治疗重型颅脑损伤的应用研究 杭州市科技局 20120533Q22

7.hsTRAIL基因抑制人类胶质瘤干细胞增值作用及其机制研究 浙江省卫生厅2014RCA023

8.脑积水患者腰大池脑脊液外引流治疗前后无创性静息态脑rCBF的fMRI研究杭州市卫生局 2014A19

9.颅内压监测下安宫牛黄丸联合EVD-LP治疗重度脑室出血的临床研究  浙江省医学会临床科研基金 2021ZYC A80

◆ 代表性论著

1.Qiu W, Chen M, Wang X, Qiu W, Chen M, Wang X.Pre-hospital mild therapeutic hypothermia for patients with severe traumatic brain injury.Brain Inj. 2022 Jan 2;36(1):72-76.  (SCI )

2.Wang M, Qiu W, Zeng Y, Fan W, Lian X, Shen Y.IMP-ICDX: an injury mortality prediction based on ICD-10-CM codes.World J Emerg Surg. 2019 Oct 11;14:46. (SCI )

3.Sun W, Shao Z, Xu H, Qiu W(Corresponding author), Sun J.Application of pulsed arterial resuscitation in a rabbit model of hemorrhagic shock.Ulus Travma Acil Cerrahi Derg. 2017 Nov;23(6):445-451. (SCI )

4.Xu H, Hu Y, Qiu W.Potential mechanisms of microRNA-129-5p in inhibiting cell processes including viability, proliferation, migration and invasiveness of glioblastoma cells U87 through targeting FNDC3B.Biomed Pharmacother. 2017 Mar;87:405-411. (SCI )

5.Wang M, Qiu WS(Corresponding author), Tangent function transformation of the Abbreviated Injury Scale improves accuracy and simplifies scoring.Arch Med Sci. 2015 Mar 16;11(1):130-6.  (SCI )

6.Qiu W, Jiang Q, Xiao G, Wang W, Shen H.Changes in intracranial pressure gradients between the cerebral hemispheres in patients with intracerebral hematomas in one cerebral hemisphere.BMC Anesthesiol. 2014 Dec 3;14:112. (SCI )

7.Wang X, Cai WW,Qiu WS, Qiu F, Lv WS. A changing of the Abbreviated Injury Scale that improves accuracy and simplifies scoring. Hong Kong J  Emerg Med 2013;20(3):138-145.  (SCI )

8.Xu Wang, Qiu WS(Corresponding author), et al. The Tangent Function Transforms the Abbreviated Injury Scale That Both Improves Accuracy and Simplifies Scoring. Archives of Medical Science.2014 (SCI )

9.Qiu W, Sun W, Guo C, Wu Z, Ding M, Shen H. Diagnosis and microsurgery of symptomatic spontaneous spinal epidural hematoma. Ir J Med Sci. 2010 (SCI )

10.Qiu W, Chenchen Guo, et al. Effects of unilateral decompressive craniectomy on patients with unilateral acute post-traumatic brain swelling after severe traumatic brain injury. Critical Care 2009, 13:R185 doi:10.1186/cc8178 (SCI )

11.Qiu W, Zhang Y, Sheng H, Zhang J, Wang W, Liu W, Chen K, Zhou J, Xu Z.Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy.J Crit Care. 2007;22(3):229-35. (SCI )

12.Qiu W, Shen H, Zhang Y, Wang W, Liu W, Jiang Q, Luo M, Manou M.Noninvasive selective brain cooling by head and neck cooling is protective in severe traumatic brain injury.J Clin Neurosci. 2006;13(10):995-1000. (SCI )

13.Liu WG, Qiu WS(Corresponding author), Zhang Y, Wang WM, Lu F, Yang XF. Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary study. J Int Med Res. 2006 Jan-Feb;34(1):58-64. (SCI )

14.Qiu WS, Wang WM, Du HY, Liu WG, Shen H, Shen LF, Zhu ML.Thrombocytopenia after therapeutic hypothermia in severe traumatic brain injury. Chin J Traumatol,2006 Aug;9(4):238-41.

15.Qiu WS, Liu WG, Shen H, Wang WM, Hang ZL, Zhang Y, Jiang SJ, Yang XF. Therapeutic effect of mild hypothermia on severe traumatic head injury. Chin J Traumatol, 2005;8:27-3

16.Qiu WS, Liu WG, Shen H, Wang WM. Management of posttraumatic brain swelling based on clinical typing. Chin J Traumatol, . 2004 Jun;7(3):175-8.

17.裘五四,沈宏,傅伟明,等. 儿童第四脑室肿瘤的临床特点和微创外科治疗[J]. 中华小儿外科杂志,2007,28(10):559-560..

18.裘五四,刘伟国,姜启周,等. 外伤后急性脑肿胀的临床分型与治疗[J]. 中华创伤杂志,2003,19(5):280-282.

19.裘五四,姜启周,陈小启,等. 脑内单发转移瘤13例诊治分析[J]. 浙江医学,2009,31(8):1117-1118. 

20.裘五四,刘伟国,张建明,等. Rathke's囊肿的诊断和显微手术治疗[J]. 医师进修杂志,2005,28(8):37-39. 

21.裘五四,姜启周,蒋群莲. 脑室腹腔分流术治疗脑积水的并发症及其防治[J]. 浙江临床医学,2004,6(2):110. 

22.裘五四,刘伟国. 脑胶质瘤分子病因及其靶向治疗的研究进展[J]. 全科医学临床与教育,2009,7(5):506-510. 

◆ 成果奖励

1.《选择性亚低温治疗大鼠脑外伤后Fas/Fas-L基因表达的影响》 获得浙江省医药卫生科技奖三等奖（2010年）

2.《院前亚低温治疗重型颅脑损伤的应用研究》   获得杭州市科技进步三等奖（2016年）

3.《亚低温治疗对重型颅骨损伤患者大脑半球Pbto2梯度的影响》   浙江省医药卫生科技奖三等奖（2015年）