车先伟

◆ 导师基本情况

姓名：车先伟，神经科学博士，副教授（硕士生导师）

办公电话：0571-28867717

邮箱：xwcheswu@gmail.com；xianwei.che@hznu.edu.cn

指导专业：临床认知神经科学（学硕）、应用心理（专硕）、非全

◆ 研究领域

1. 无创神经调控技术（TMS, TIS, TFUS）调节抑郁、疼痛的实验与临床研究

2. 无创神经调控技术（TMS, TIS, TFUS）的作用机制与优化研究

◆ 主讲课程

1. 无创神经调控治疗原理和案例

◆ 教育和工作经历

2008年9月--2012年6月，山东工商学院，社会工作学士

2012年9月--2015年6月，西南大学，认知神经科学硕士

2015年9月--2019年6月，MONASH UNIVERSITY，神经科学博士

2019年11月至今，杭州师范大学临床医学院副教授

◆ 学术简介

   硕士生导师，研究领域为无创神经调控技术（TMS, TIS, TFUS）调节疼痛、抑郁及其神经可塑性机制研究。主持国家自然科学基金项目、浙江省“尖兵”重点研发计划课题、浙江省自然科学基金项目等。以第一或通讯作者发表领域高水平期刊论文多篇，包括IF>10分文章2篇（Cell Reports Medicine, Biological Psychiatry）, 中科院TOP期刊>10篇（Brain Stimulation 5篇, PAIN, NeuroImage等）。培养博士生2人（浙江大学医学院联合导师）、硕士研究生近30人。讲授《无创神经调控治疗原理和案例》等研究生课程。

◆ 主持教学科研项目

1. 浙江省自然科学基金项目，研究延长性theta节律刺激（pcTBS）的镇痛效应及其神经可塑性机制，10万元，202301-202512。

2. 浙江省重点研发计划课题，面向脑机接口的外部信息输入与神经调控技术研究，50万元，202201-202512。

3. 国家自然科学基金，探索重复经颅磁刺激（rTMS）在慢性神经病理性疼痛中的持续镇痛效应及其神经可塑性机制，30万元，202101-202312。

4. 杭州师范大学人才引进科研启动经费，经颅磁刺激缓解慢性疼痛的基础研究与临床转化，80万元，202303-202703

◆ 代表性论著（*通讯作者，H指数21，总引用1610次）

1. Xianwei Che, Haoyang Zhao, Xinyi Ye, Shaoyong Ye, Zhen Zhen, Zhimin Huang, Ying Li, Shiyi Zhang, Pengfeng Xu, Xuanqiang Chen, Chaonan Jiang, Fen Pan, Honglin Luan, Jingkai Chen, Desheng Shang, Shaohua Hu, Yiheng Tu, Li Hu, Bernadette M. Fitzgibbon, Paul B. Fitzgerald, Robin F. H. Cash, Manli Huang* The Frontoparietal Network Mediates the Antidepressant Effects of Accelerated Intermittent and Continuous Theta Burst Stimulation: A Randomised Controlled Trial and TMS-EEG Study. Cell Reports Medicine (中科院TOP期刊，第一作者).

2. Zhen Zhen; Li Yunze; Zhou Jie; Li Han; Zalesky Andrew; Cash Robin; Feng Zhiying; Che Xianwei*; Prospective open-label trial of personalised connectivity-guided transcranial magnetic stimulation therapy for migraine, The Journal of Headache and Pain, 2026, 27(44): 1-10 (中科院TOP期刊，通讯作者)

3. Haoyang Zhao, Chaonan Jiang, Miaomiao Zhao, Yang Ye, Liang Yu, Ying Li, Honglin Luan, Shiyi Zhang, Pengfeng Xu, Xuanqiang Chen, Fen Pan, Desheng Shang, Xiaohan Hu, Kangyu Jin, Jingkai Chen, Tingting Mou, Shaohua Hu, Bernadette M Fitzgibbon, Paul B Fitzgerald, Robin FH Cash, Xianwei Che*, Manli Huang*. Comparisons of Accelerated Continuous and Intermittent Theta-burst Stimulation for Treatment-Resistant Depression and Suicidal Ideation. Biological Psychiatry, 2023 (中科院TOP期刊，共同通讯作者).

4. Yuchao Chen, Jie Zhou, Zhouyao Hu, Yi Jin, Bolin Tan, Ying Wang, Yi Sha, Qiusi Cai, Yijun Chen, Yuchen Wang, Mingyue Qu, Zhiyuan You, Yimeng Shao, Yingying Zhu, Zhongming Gao, Yang Bai, Guilin Meng, Pengfei Xu, Dongsheng Xu, Paul B. Fitzgerald, Xianwei Che*. Cerebello-cortical Inhibition Underlies the Effects of Cerebellar Magnetic Stimulation on Spinocerebellar Ataxia Type 3: A Randomized Controlled Trial. Brain Stimulation 2025 (中科院TOP期刊，通讯作者，神经调控方向排名第一杂志).

5. J Zhou, Y Wang, X Luo, PB Fitzgerald, RFH Cash, BM Fitzgibbon, X Che^*. Revisiting the effects of rTMS over the dorsolateral prefrontal cortex on pain: An updated systematic review and meta-analysis. Brain Stimulation, 2024. (中科院TOP期刊，通讯作者，神经调控方向排名第一杂志).

6. *Che, X., Fitzgibbon B., Yang, Y., Wang, J., Luo, H., Fitzgerald, P., &, Cash, R. Characterising the Optimal Pulse Number and Frequency for Inducing Analgesic Effects with Motor Cortex rTMS. Brain Stimulation, 2021, 14:1081-1083 (中科院TOP期刊，通讯作者，神经调控方向排名第一杂志).

7. *Xianwei Che, Robin F.H. Cash, Xi Luo, Hong Luo, Xiaodong Lu, Feng Xu, Yu-Feng Zang, Paul B. Fitzgerald, Bernadette M. Fitzgibbon. High-frequency rTMS over the dorsolateral prefrontal cortex on chronic and provoked pain: A systematic review and meta-analysis. Brain Stimulation, 2021, 14:1135-1146 (中科院TOP期刊，通讯作者，神经调控方向排名第一杂志).

8. J Li, K Xu, Y Guo, X Chen, G Li, L Qi, X ^*Che. Case evidence of repetitive transcranial magnetic stimulation in the management of refractory irritable bowel syndrome with comorbid depression. Brain Stimulation, 2022, 15:434-436 (中科院TOP期刊，通讯作者，神经调控方向排名第一杂志).

9. Y Wang, B Tan, S Shi, Y Ye, Xianwei Che^*. Dopamine D2 receptor antagonist modulates rTMS-induced pain experiences and corticospinal excitability dependent on stimulation targets. International Journal of Clinical and Health Psychology 2024, 24 (1), 100413. (中科院TOP期刊，通讯作者).

10. Che X*, R Cash, SW Chung, N Bailey, PB Fitzgerald, BM Fitzgibbon. The dorsomedial prefrontal cortex as a flexible hub mediating behavioral as well as local and distributed neural effects of social support context on pain: A Theta Burst Stimulation and TMS-EEG study. Neuroimage. 2020 (中科院TOP期刊，通讯作者)

11. Yazhen Han, Zhimin Huang, Yujun Wang, Ying Liu, Jiqing He, Zhongming Gao, Paul B Fitzgerald, Zafiris J Daskalakis, Xianwei Che^*. Excitatory magnetic stimulation increased interhemispheric inhibition: a pharmacological and TMS-EEG study. Cerebral Cortex, 2025, 35 (11), bhaf310.

12. Ye Y, Wang J, Che X*. Concurrent TMS-EEG to Reveal the Neuroplastic Changes in the Prefrontal and Insular Cortices in the Analgesic Effects of DLPFC-rTMS. Cerebral Cortex , 2022 (中科院二区，通讯作者).

13. J Chen, Y Fan, X Jia, F Fan, J Wang, Q Zou, B Chen, X Che^*, Y Lv. The Supplementary Motor Area as a Flexible Hub Mediating Behavioral and Neuroplastic Changes in Motor Sequence Learning: A TMS and TMS-EEG Study. Neuroscience Bulletin 41(5), 2025, 37-852 (中科院二区，共同通讯作者)

14. Z Huang, Y Wang, Y Yan, Y Liu, J Chen, H Liu, J Li, Z Gao, X Che^*. Identifying neural circuitry abnormalities in neuropathic pain with transcranial magnetic stimulation and electroencephalogram co-registration. Neurotherapeutics, 2024, e00496. (中科院二区，通讯作者).

15. Bolin Tan, Jielin Chen, Ying Liu, Qiuye Lin, Ying Wang, Shuyan Shi, Yang Ye, Xianwei Che*. Differential analgesic effects of high-frequency or accelerated intermittent theta burst stimulation of M1 on experimental tonic pain: Correlations with cortical activity changes assessed by TMS-EEG. Neurotherapeutics, 2024, e00451. (中科院二区，通讯作者).

16. Ming Cheng, *Xianwei Che, Yang Ye, Changlin He, Liang Yu, Yating Lv, Paul B Fitzgerald, Robin F. H. Cash, Bernadette M. Fitzgibbon. Analgesic efficacy of theta-burst stimulation for postoperative pain. Clinical Neurophysiology, 2023. (中科院二区，通讯作者)

17. X Che^*, R Cash, S Chung, P Fitzgerald, B Fitzgibbon. Investigating the influence of social support on experimental pain and related physiological arousal: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 2018(中科院TOP期刊，通讯作者)

◆ 学术组织

· 中国认知科学学会认知与脑调控分会委员

· 中国心理学会认知神经科学学会分会委员

· 浙江省神经科学学会神经调控分会副主任委员

· 浙江省神经科学学会理事

· 国际疼痛学会会员