卢雁薇

一、导师基本情况

1.肿瘤学博士，主治医师，硕士生导师

2.邮箱：luyanwei@qq.com

3.指导专业：放射肿瘤学

二、研究领域

蛋白质翻译后修饰，肿瘤放疗抵抗

三、主讲课程

放射肿瘤学

四、教育和工作经历

1.教育经历：

2016-09至2019-06，华中科技大学，肿瘤学，博士

2014-09至2016-06，华中科技大学，肿瘤学，硕士

2009-0至2014-06，苏州大学，放射医学，学士

2.工作经历：

2023-01至今，浙江省人民医院，放疗科，主治医师

2019-08至2022-12，浙江省人民医院，放疗科，住院医师

五、主持教学科研项目

1.国家自然科学基金委员会青年科学基金项目，82203377，FBXW7介导SNX8泛素化修饰抑制PI3K/AKT/mTOR信号通路调控肺癌放疗抵抗的作用机制研究，30万元，202301-202512

2.浙江省自然科学基金项目，LQ22H160036，β-Trcp介导的LZTS3泛素化修饰激活Hippo/TAZ信号通路促进肺癌放疗抵抗的作用及机制研究，10万元，202201-202412

3.浙江省医药卫生科技计划项目，2022KY537，LZTS2与p53相互作用在食管癌放疗抵抗中的作用及机制研究，3万元，202201-202412

六、代表性论著

1. Y. Zeng, X. Wang, J. Hu, C. Tian, R. Liu, X. Chen, L. Huang, X. Liang, X. Wang, H. Fan, H. Zhang, and Y. Lu, LZTS3 represses tumorigenesis and radioresistance via CK1δ and β-TrCP-mediated ubiquitination pathway in lung cancer. Cellular Signalling, 2025. 129:111655.

2. D. Nan, W. Yao, L. Huang, R. Liu, X. Chen, W. Xia, H. Sheng, H. Zhang, X. Liang, and Y. Lu, Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets. Cell Communication and Signaling, 2025. 23(1):45.

3. A. Zheng, H. Xu, Y. Tao, B. Chen, J. Ding, T. Song, and Y. Lu, Comparative evaluation of TNM staging systems (eighth vs. ninth edition) for the non-surgical treatment of localized and locally advanced anal squamous cell carcinoma: Prognostic significance of T classification and lymph node status. PLoS One, 2025. 20(1):e0317598.

4. R. Liu, Y. Lu, J. Li, W. Yao, J. Wu, X. Chen, L. Huang, D. Nan, Y. Zhang, W. Chen, Y. Wang, Y. Jia, J. Tang, X. Liang, and H. Zhang, Annexin A2 combined with TTK accelerates esophageal cancer progression via the Akt/mTOR signaling pathway. Cell Death & Disease, 2024. 15(4):291.

5. X. Wang, H. Zhang, and Y. Lu, Breast metastasis of signet ring cell carcinoma from the colon: a case report. World Journal of Surgical Oncology, 2022. 20(1):376.

6. Y. Lu, C. Xu, H. Wang, T. Song, S. Wu, X. Liang, and H. Xu, Long-Term Survival Outcomes and Comparison of Different Treatment Modalities for Stage I-III Cervical Esophageal Carcinoma. Frontiers in Medicine, 2021. 8:714619.

7. Y. Lu, J. Ma, Y. Li, J. Huang, S. Zhang, Z. Yin, J. Ren, K. Huang, G. Wu, K. Yang, and S. Xu, CDP138 silencing inhibits TGF-beta/Smad signaling to impair radioresistance and metastasis via GDF15 in lung cancer. Cell Death & Disease, 2017. 8(9):e3036.

8. J. Ma, Y. Lu, S. Zhang, Y. Li, J. Huang, Z. Yin, J. Ren, K. Huang, L. Liu, K. Yang, G. Wu, and S. Xu, beta-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer. Cell Death and Differentiation, 2018. 25(8):1473-1485.

9. S. Li, W. Yao, R. Liu, L. Gao, Y. Lu, H. Zhang, and X. Liang, Long non-coding RNA LINC00152 in cancer: Roles, mechanisms, and chemotherapy and radiotherapy resistance. Front Oncol, 2022. 12:960193.

10. W. Yao, S. Li, R. Liu, M. Jiang, L. Gao, Y. Lu, X. Liang, and H. Zhang, Long non-coding RNA PVT1: A promising chemotherapy and radiotherapy sensitizer. Front Oncol, 2022. 12:959208.

11. Y. Huang, X. Yang, Y. Lu, Y. Zhao, R. Meng, S. Zhang, X. Dong, S. Xu, and G. Wu, UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance. Cell Death and Differentiation, 2021. 28(2):671-684.

12. X. Wang, Y. Lu, Z. Qin, H. Guo, W. Chen, T. Ding, J. Tang, and H. Zhang, Stereotactic Body Radiotherapy and Conventional Radiotherapy Induce Cytoskeleton Extension and Enlargement of Cell Morphology in Non-Small Cell Lung Cancer. Dose Response, 2021. 19(4):15593258211064499.

13. H. Zhang, W. Yao, M. Zhang, Y. Lu, J. Tang, M. Jiang, X. Mou, G. You, and X. Liang, TTK inhibitor promotes radiosensitivity of liver cancer cells through p21. Biochemical and Biophysical Research Communications, 2021. 550:84-91.

14. J. Lian, H. Zhang, F. Wei, Q. Li, Y. Lu, B. Yu, L. Yu, X. Liang, Y. Wen, K. Jin, J. Tang, and W. Xie, Long non-coding RNA DANCR promotes colorectal tumor growth by binding to lysine acetyltransferase 6A. Cellular Signalling, 2020. 67:109502.

15. Q. Li, Y. Jiang, G. Zhong, Y. Lu, T. Song, Y. Zhang, J. Wu, M. Zhang, X. Liang, L. Zhou, J. Tang, and H. Zhang, Long Noncoding RNA DANCR Regulates Cell Proliferation by Stabilizing SOX2 mRNA in Nasopharyngeal Carcinoma. American Journal of Pathology, 2020. 190(12):2343-2354.

16. T. Song, L. Chen, H. Zhang, Y. Lu, K. Yu, W. Zhan, and M. Fang, Multimodal treatment based on thyroidectomy improves survival in patients with metastatic anaplastic thyroid carcinoma: a SEER analysis from 1998 to 2015. Gland Surgery, 2020. 9(5):1205-1213.

17. S. Xu, Y. Li, Y. Lu, J. Huang, J. Ren, S. Zhang, Z. Yin, K. Huang, G. Wu, and K. Yang, LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85. Cancer Letters, 2018. 420:38-48.

18. H. Zhang, C. Wan, J. Huang, C. Yang, Y. Qin, Y. Lu, J. Ma, B. Wu, S. Xu, G. Wu, and K. Yang, In Vitro Radiobiological Advantages of Hypofractionation Compared with Conventional Fractionation: Early-Passage NSCLC Cells are Less Aggressive after Hypofractionation. Radiation Research, 2018. 190(6):584-595.

19. Q. Wang, J. Ma, Y. Lu, S. Zhang, J. Huang, J. Chen, J.X. Bei, K. Yang, G. Wu, K. Huang, J. Chen, and S. Xu, CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells. Oncogene, 2017. 36(37):5321-5330.