卢雁薇

◆导师基本情况

1.肿瘤学博士，主治医师，硕士生导师

2.邮箱：luyanwei@qq.com

3.指导专业：放射肿瘤学

◆研究领域

蛋白质翻译后修饰，肿瘤放疗抵抗

◆主讲课程

放射肿瘤学

◆教育和工作经历

1.教育经历：

2016-09至2019-06，华中科技大学，肿瘤学，博士

2014-09至2016-06，华中科技大学，肿瘤学，硕士

2009-0至2014-06，苏州大学，放射医学，学士

2.工作经历：

2023-01至今，浙江省人民医院，放疗科，主治医师

2019-08至2022-12，浙江省人民医院，放疗科，住院医师

◆学术任职

无

◆主持教学科研项目

1.国家自然科学基金委员会青年科学基金项目，82203377，FBXW7介

导SNX8泛素化修饰抑制PI3K/AKT/mTOR信号通路调控肺癌放疗抵抗

的作用机制研究，30万元，202301-202512

2.浙江省自然科学基金项目，LQ22H160036，β-Trcp介导的LZTS3

泛素化修饰激活Hippo/TAZ信号通路促进肺癌放疗抵抗的作用及机

制研究，10万元，202201-202412

3.浙江省医药卫生科技计划项目，2022KY537，LZTS2与p53相互作

用在食管癌放疗抵抗中的作用及机制研究，3万元，202201-202412

◆代表性论著

1.Y.Lu,X.Li,H.Liu,J.Xue,Z.Zeng,X.Dong,T.Zhang,G.Wu,K.

Yang,andS.Xu,β-TrcpandCK1δ-mediateddegradationofLZTS2

activatesPI3K/AKTsignalingtodrivetumorigenesisandmetastasis

inhepatocellularcarcinoma.Oncogene,2021.40(7):1269-1283.

2.Y.Lu,C.Xu,H.Wang,T.Song,S.Wu,X.Liang,andH.Xu,

Long-TermSurvivalOutcomesandComparisonofDifferent

TreatmentModalitiesforStageI-IIICervicalEsophagealCarcinoma.

FrontiersinMedicine,2021.8:714619.

3.J.Ma,Y.Lu,S.Zhang,Y.Li,J.Huang,Z.Yin,J.Ren,K.Huang,L.

Liu,K.Yang,G.Wu,andS.Xu,beta-TrcpubiquitinligaseandRSK2

kinase-mediateddegradationofFOXN2promotestumorigenesisand

radioresistanceinlungcancer.CellDeathandDifferentiation,2018.

25(8):1473-1485.

4.X.Wang,H.Zhang,andY.Lu,Breastmetastasisofsignetringcell

carcinomafromthecolon:acasereport.WorldJSurgOncol,2022.

20(1):376.

5.S.Li,W.Yao,R.Liu,L.Gao,Y.Lu,H.Zhang,andX.Liang,Long

non-codingRNALINC00152incancer:Roles,mechanisms,and

chemotherapyandradiotherapyresistance.FrontOncol,2022.

12:960193.

6.W.Yao,S.Li,R.Liu,M.Jiang,L.Gao,Y.Lu,X.Liang,andH.

Zhang,Longnon-codingRNAPVT1:Apromisingchemotherapyand

radiotherapysensitizer.FrontOncol,2022.12:959208.

7.Y.Huang,X.Yang,Y.Lu,Y.Zhao,R.Meng,S.Zhang,X.Dong,S.

Xu,andG.Wu,UBE2OtargetsMxi1forubiquitinationand

degradationtopromotelungcancerprogressionandradioresistance.

CellDeathandDifferentiation,2021.28(2):671-684.

8.X.Wang,Y.Lu,Z.Qin,H.Guo,W.Chen,T.Ding,J.Tang,andH.

Zhang,StereotacticBodyRadiotherapyandConventional

RadiotherapyInduceCytoskeletonExtensionandEnlargementof

CellMorphologyinNon-SmallCellLungCancer.DoseResponse,

2021.19(4):15593258211064499.

9.H.Zhang,W.Yao,M.Zhang,Y.Lu,J.Tang,M.Jiang,X.Mou,G.

You,andX.Liang,TTKinhibitorpromotesradiosensitivityofliver

cancercellsthroughp21.BiochemicalandBiophysicalResearch

Communications,2021.550:84-91.

10.J.Lian,H.Zhang,F.Wei,Q.Li,Y.Lu,B.Yu,L.Yu,X.Liang,Y.

Wen,K.Jin,J.Tang,andW.Xie,Longnon-codingRNADANCR

promotescolorectaltumorgrowthbybindingtolysine

acetyltransferase6A.CellularSignalling,2020.67:109502.

11.Q.Li,Y.Jiang,G.Zhong,Y.Lu,T.Song,Y.Zhang,J.Wu,M.Zhang,

X.Liang,L.Zhou,J.Tang,andH.Zhang,LongNoncodingRNA

DANCRRegulatesCellProliferationbyStabilizingSOX2mRNAin

NasopharyngealCarcinoma.AmericanJournalofPathology,2020.

190(12):2343-2354.

12.T.Song,L.Chen,H.Zhang,Y.Lu,K.Yu,W.Zhan,andM.Fang,

Multimodaltreatmentbasedonthyroidectomyimprovessurvivalin

patientswithmetastaticanaplasticthyroidcarcinoma:aSEER

analysisfrom1998to2015.GlandSurgery,2020.9(5):1205-1213.

13.J.Huang,Y.Qin,C.Yang,C.Wan,X.Dai,Y.Sun,J.Meng,Y.Lu,Y.

Li,Z.Zhang,B.Wu,S.Xu,H.Jin,andK.Yang,Downregulationof

ABI2expressionbyEBV-miR-BART13-3pinduces

epithelial-mesenchymaltransitionofnasopharyngealcarcinomacells

throughupregulationofc-JUN/SLUGsignaling.Aging,2020.

12(1):340-358.

14.S.Xu,Y.Li,Y.Lu,J.Huang,J.Ren,S.Zhang,Z.Yin,K.Huang,G.

Wu,andK.Yang,LZTS2inhibitsPI3K/AKTactivationand

radioresistanceinnasopharyngealcarcinomabyinteractingwithp85.

CancerLetters,2018.420:38-48.

15.H.Zhang,C.Wan,J.Huang,C.Yang,Y.Qin,Y.Lu,J.Ma,B.Wu,S.

Xu,G.Wu,andK.Yang,InVitroRadiobiologicalAdvantagesof

HypofractionationComparedwithConventionalFractionation:

Early-PassageNSCLCCellsareLessAggressiveafter

Hypofractionation.RadiationResearch,2018.190(6):584-595.

16.Y.Qin,L.Lu,Y.Lu,andK.Yang,Hodgkinlymphomainvolvingthe

tonsilmisdiagnosedastonsillarcarcinoma.Medicine,2018.

97(7):e9761.

17.Y.Qin,Y.Lu,L.Zheng,andH.Liu,Ghostcellodontogenic

carcinomawithsuspectedcholesterolgranulomaofthemaxillary

sinusinapatienttreatedwithcombinedmodalitytherapy.Medicine,

2018.97(7):e9816.

18.Q.Wang,J.Ma,Y.Lu,S.Zhang,J.Huang,J.Chen,J.X.Bei,K.

Yang,G.Wu,K.Huang,J.Chen,andS.Xu,CDK20interactswith

KEAP1toactivateNRF2andpromotesradiochemoresistanceinlung

cancercells.Oncogene,2017.36(37):5321-5330.

◆成果奖励

无

◆授权专利及转化

无