毕擎

◆导师基本情况

1.毕擎，主任医师，教授，硕士研究生导师/博士生导师

2.邮箱：bqzjsrmyy@163.com

3.指导专业：骨科（关节外科与运动医学）

◆研究领域

1.骨与软骨再生修复；2.干细胞应用于骨关节炎的治疗研究；

3.关节损伤的微创的治疗研究

◆主讲课程

骨折概论

◆教育和工作经历

1.教育经历：

1987.09-1992.06遵义医科大学本科

2005.09-2008.06温州医科大学硕士研究生

2014.09-2018.12苏州大学博士研究生

2.工作经历：

1992.08-1998.11浙江省人民医院住院医师

1998.12-2003.11浙江省人民医院主治医师

2003.11-2008.11浙江省人民医院副主任医师

2008.12-至今浙江省人民医院主任医师

2010.08-2016.04浙江省人民医院骨科科室副主任

2016.04-至今浙江省人民医院骨科科室主任

◆学术任职

中华医学会运动医疗分会常务委员、中华医学会运动医疗分会上肢学组副组长、中华医学会骨科分会关节镜学组委员、中国医师协会骨科分会委员、中国医师协会骨科分会转化医学学组副组长、中国医师协会运动医学分会委员、浙江省医学会运动医学分会候任主委、浙江省医学会骨科分会副主任委员、浙江省医学会组织再生与修复分会副主任委员、浙江省医师协会骨科分会副会长、浙江省医师协会运动医学分会副会长、浙江省体育科学学会运动医学专业委员会主任委员、浙江省康复医学会运动医学专业委员会主任委员

◆主持教学科研项目

现主持课题：

1.肌肉骨骼系统疾病诊治新技术研究-脐带和脂肪间充质干细胞联合治疗膝关节骨关节炎的临床创新技术转化研究浙江省科技厅重大研发项目

2.胞外基质对股骨头坏死病灶及腱骨愈合修复作用及机制研究国家科技资源共享服务平台项目

◆代表性论著

Zhang, W., Ji, L., Wang, X., Zhu, S., Luo, J., Zhang, Y., Tong, Y., Feng, F., Kang, Y., & Bi, Q. (2022). Nomogram Predicts Risk and Prognostic Factors for Bone Metastasis of Pancreatic Cancer: A Population-Based Analysis. Frontiers in endocrinology, 12, 752176. 

Meng, X., Sun, L., Meng, X., & Bi, Q. (2024). The protective effect of Ergolide in osteoarthritis: In vitro and in vivo studies. International immunopharmacology, 127, 111355. 

Luo, J., Zhu, S., Tong, Y., Zhang, Y., Li, Y., Cao, L., Kong, M., Luo, M., Bi, Q., & Zhang, Q. (2023). Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway. Biological trace element research, 201(2), 865–873. 

Meng, X., Meng, X., He, Z., Yuan, Y., Fan, Y., Yin, L., Tong, Y., Hong, Z., Zhu, S., Zhang, Q., & Bi, Q. (2023). Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury. Biological trace element research, 10.1007/s12011-023-04003-5. Advance online publication. 

Hong, Z., Zhang, Y., Chen, J., & Bi, Q. (2023). Adipose-derived stromal vascular fraction injection following core decompression and biochemistry artificial bone graft implantation in osteonecrosis of the femoral head. International orthopaedics, 47(6), 1481–1486.

 Fan, Y., Yin, L., Zhong, X., He, Z., Meng, X., Chai, F., Kong, M., Zhang, Q., Xia, C., Tong, Y., & Bi, Q. (2024). An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis. Journal of ethnopharmacology, 326, 117827. 

Yao, K., Xiaojun, Z., Tingxiao, Z., Shiyao, L., Lichen, J., Wei, Z., Yanlei, L., Jinlong, T., Xiaoyan, D., Jun, Z., Qing, B., & Jun, L. (2023). Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer. BMC cancer, 23(1), 1213. 

Zhu, S., Ji, L., He, Z., Zhang, W., Tong, Y., Luo, J., Hong, Z., Zhang, Y., Yu, D., Zhang, Q., & Bi, Q. (2023). Association of smoking and osteoarthritis in US (NHANES 1999-2018). Scientific reports, 13(1), 3911. 

Zhong, X., Lin, Y., Zhang, W., & Bi, Q. (2023). Predicting diagnosis and survival of bone metastasis in breast cancer using machine learning. Scientific reports, 13(1), 18301. 

Luo, J., Zhang, Y., Zhu, S., Tong, Y., Ji, L., Zhang, W., Zhang, Q., & Bi, Q. (2021). The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis. Naunyn-Schmiedeberg's archives of pharmacology, 394(10), 1991–2002. 

◆成果奖励

无

◆授权专利及转化

无