王吉

◆导师基本情况
1.肿瘤学博士，副研究员、医师，硕士生导师

2.邮箱：jiwang1004@zju.edu.cn

3.指导专业：整形外科；基础医学

4.个人简介：

哈佛大学博士后，整形外科临床医生，目前共已发表 SCI 论文 23篇，其中以第一或共同第一作者发表 SCI 论文 14 篇，累计影响因子 125分。为人热情，关心学生，有责任心，带教能力强。

◆研究领域

肿瘤代谢与免疫、3D打印、器官再生。

◆主讲课程

医学英语、科研思维训练

◆教育和工作经历

1.教育经历：

2007/09-2012/06  浙江中医药大学 临床医学

2012/09-2015/06  浙江大学医学院硕士研究生

2015/09-2020/12  浙江大学医学院博士研究生

2017/11-2020/12  哈佛大学医学院博士后 

2.工作经历：

2021/05-至今  浙江省人民医院 整形外科

◆学术任职

中国研究型医院学会整形外科学 青委副主委

浙江省医学会整形外科学 青委副主委

浙江省医学会组织修复与再生分会 委员

浙江省整形美容行业协会眼整形与美容分会  委员

中华医学会微创美容专业学组 委员

中华医学会数字化学组 委员

七、主持教学科研项目

1.国家自然科学基金，青年项目，82203602，PSAT1介导丝氨酸代谢重塑促进三阴性乳腺癌免疫逃逸的机制研究，经费30万，在研，主持

2.国家自然科学基金，重点课题，52235007，离散阵列发散光路设计理论及双分辨率光固化增材制造方法研究，经费53万，在研，子课题负责人

3. 浙江省自然科学基金委员会，探索项目，LQ22H160020，LncRNA H19促进他莫昔芬耐药乳腺癌分泌丝氨酸诱导CD63+肿瘤相关成纤维细胞形成的机制研究，10万，在研，主持

4. 浙江省人民医院优秀科研启动基金，ZRY2021A001，他莫昔芬耐药乳腺癌通过lncRNA H19/PHGDH/丝氨酸轴诱导巨噬细胞M2极化的机制研究，8万，在研，主持

5. 杭州医学院2021年度高校青年科研基金项目，KYQN202109，他莫昔芬耐药乳腺癌通过lncRNA H19/PHGDH/丝氨酸轴诱导巨噬细胞M2极化的机制研究, 3万，

◆代表性论著

第一、共同第一作者或通讯作者论文

1. Ji Wang(王吉); Chao Chen; Lu Wang; Mingjun Xie; Xinyang Ge; Sufan Wu; Yong He; Xiao Z Mou; Chen yang Ye; Yi Sun ; Patient-derived tumor organoids: New progress and opportunities to facilitate p recision cancer immunotherapy, Frontiers in Oncology, 2022, DOI: 10.3389/(fonc.2022.872531). （代表文章 IF=6.244）

2. Ji Wang(王吉), Harilaos Filippakis, Thomas Hougard, Heng Du, Chenyang Ye, Heng-Jia Liu, Khadijah Hindi, Shefali Bagwe, Julie Nijmeh, John M. Asara, Wei Shi, Souheil El-Chemaly, Elizabeth P. Henske(*), Hilaire C. Lam(*). Interleukin-6 induces PSAT1 expression in Tsc2-deficient cells to support serine metabolism. Proceedings of the National Academy of Sciences. 2021 （代表文章 IF=11.205）

3. Ji Wang(王吉), Shuduo Xie, Jingjing Yang, Hanchu Xiong, Yunlu Jia, Yulu Zhou, Yongxia Chen, Xiaogang Ying, Cong Chen, Chenyang Ye, Linbo Wang(*) and Jichun Zhou(*). The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy. Journal of Hematology & Oncology. 2019 Jul 24;12(1):81.（代表文章 IF=17.833）

4. Ji Wang(王吉)(#), Chenyang Ye(#), Cong Chen, Hanchu Xiong, Binbin Xie, Jichun Zhou, Yongxia Chen, Shu Zheng (*), Linbo Wang (*). Glucose Transporter GLUT1 Expression and Clinical Outcome in Solid Tumors: A Systematic Review and Meta-Analysis. Oncotarget. 2017 Mar 7;8(10):16875-16886.

5. Ji Wang(王吉)(#), Chenyang Ye (#), Demin Lu(#), Yongxia Chen, Yunlu Jia, Xiaogang Ying, Hanchu Xiong, Wenhe Zhao(*), Jichun Zhou(*) and Linbo Wang(*). Matrix metalloproteinase-1 expression in breast carcinoma: a marker for unfavorable prognosis. Oncotarget. 2017 Aug 24;8(53):91379-91390.

6. Chenyang Ye(#), Lina Qi(#), Ji Wang(王吉)(#), Shu Zheng(*). COVID-19 pandemic: advances in diagnosis, treatment, organoid applications and impacts on cancer patient management. Frontiers in Medicine. 2021 Mar 29;8:606755.

7. Ji Wang(王吉)(#), Chenyang Ye(#), Hanchu Xiong, Yong Shen, Yi Lu, Jichun Zhou(*), Linbo Wang(*). Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication. Oncotarget. 2017 Jan 17;8(3):5508-5522.

8. Chenyang Ye(#), Ji Wang(王吉)(#), Wenshan Li, Ying Chai(*). Novel Strategy for Synchronous Multiple Primary Lung Cancer Displaying Unique Molecular Profiles. The Annals of Thoracic Surgery. 2016; 101(2):e45-7.

9. Chenyang Ye(#), Ji Wang(王吉)(#), Pin Wu, Xiaofen Li, Ying Chai(*). Prognostic role of cyclin B1 in solid tumors: a meta-analysis. Oncotarget. 2017 Jan 10;8(2):2224-2232.

10. Hanchu Xiong(#), Wenhe Zhao(#), Ji Wang(#), Benjamin J. Seifer, Chenyang Ye, Yongxia Chen, Yunlu Jia, Cong Chen, Jianguo Shen, Linbo Wang(*), Xinbing Sui(*), Jichun Zhou(*). Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities. Oncotarget. 2017 Apr 11;8(15):25721-25735.

11. Hanchu Xiong(#), Ji Wang(王吉)(#), Yunlu Jia, Chenyang Ye, Yi Lu, Cong Chen, Jianguo Shen, Yongxia Chen, Wenhe Zhao, Linbo Wang(*), Jichun Zhou(*). Laparoscopic surgery versus open resection in patients with gastrointestinal stromal tumors: An updated systematic review and meta-analysis. The American Journal of Surgery. 2017 Sep;214(3):538-546.

12. Chenyang Ye(#), Ji Wang(王吉)(#), Shu Zheng, Ying Chai(*). Effective treatment with icotinib in lung adenocarcinoma with EGFR and ALK co-alterations and brain metastasis. OncoTargets and Therapy. 2016; 9:6605-6608.

13. Chenyang Ye(#), Ji Wang(王吉) (#), Ying Chai(*). Vanishing Lung Syndrome With Air-Fluid Levels. The American Journal of the Medical Sciences. 2016; 352(1): e1.

14. Chenyang Ye(#), Ji Wang(王吉) (#), Wenshan Li, Mingjing Yuan, Ying Chai(*). Effective treatment of advanced alveolar soft part sarcoma with sunitinib: A case report. Medicine. 2018 Dec;97(51):e13584.非第一或共同第一作者论文

15. Andrii Kovalenko, Andres Sanin, Kosmas Kosmas, Long Zhang, Ji Wang(王吉), Elie W. Akl, Hilaire C. Lam, David J. Kwiatkowski, Elizabeth P. Henske(*), Harilaos Filippakis(*), Therapeutic targeting of DGKA-mediated macropinocytosis leads to phospholipid reprogramming in Tuberous Sclerosis Complex. Cancer Research. 2021 Apr 15;81(8):2086-2100.

16. Chenyang Ye(#), Lina Qi(#), Xiaofen Li(#), Ji Wang(王吉), Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen, Shu Zheng(*). Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level. Cell Communication Signaling. 2020 Jan 31;18(1):16.

17. Xiong, Hanchu; Shen, Jianguo; Chen, Zihan; Yang, Jingjing; Xie, Bojian; Jia, Yunlu; Jayasinghe, Ushani; Wang, Ji(王吉); Zhao, Wenhe; Xie, Shuduo; Wang, Linbo; Zhou, Jichun. H19/let?7/Lin28 ceRNA network mediates autophagy inhibiting epithelial?mesenchymal transition in breast cancer. International Journal of Oncology. 2020 Mar;56(3):794-806.

18. Chen, Cong, Huang, Shumin, Huang, Aihua, Jia, Yunlu, Wang, Ji(王吉), Zhang, Zeqin, Mao, Misha, Wang, Linbo, Zhou, Jichun. Risk factors for lymph node metastasis and the impact of adjuvant chemotherapy on ductal carcinoma in situ with microinvasion: a population-based study. OncoTargets and Therapy. 2018 Dec 13;11:9071-9080.

19. Chen, Cong, Huang, Shumin, Huang, Aihua, Jia, Yunlu, Wang, Ji(王吉), Mao, Misha, Zhou, Jichun, Wang, Linbo. Total endoscopic thyroidectomy versus conventional open thyroidectomy in thyroid cancer: a systematic review and meta-analysis. Therapeutics and Clinical Risk Management. 2018 Dec 5;14:2349-2361.

20. Jia, Yunlu, Zhou, Jichun, Luo, Xiao; Chen, Miao, Chen, Yongxia, Wang, Ji(王吉), Xiong, Hanchu; Ying, Xiaogang; Hu, Wenxian; Zhao, Wenhe; Deng, Wuguo; Wang, Linbo. KLF4 overcomes tamoxifen resistance by suppressing MAPK signaling pathway and predicts good prognosis in breast cancer. Cellular Signalling, January 2018, Vol.42, pp.165-175

21. Zhou, Jichun; Shen, Jianguo; Seifer, Benjamin J; Jiang, Shaojie; Wang, Ji(王吉); Xiong, Hanchu; Xie, Lingmin; Wang, Linbo; Sui, Xinbing. Approaches and genetic determinants in predicting response to neoadjuvant chemotherapy in locally advanced gastric cancer. Oncotarget. 2017, Vol.8(18), p.30477-30494.

22. Yunlu Jia, Yongxia Chen, Qinchuan Wang, Ushani Jayasinghe, Xiao Luo, Qun Wei, Ji Wang(王吉), Hanchu Xiong, Cong Chen, Bin Xu, Wenxian Hu, Linbo Wang, Wenhe Zhao, and Jichun Zhou. Exosome: emerging biomarker in breast cancer. Oncotarget, 2017 Jun 20, Vol.8(25), pp.41717-41733.

23. Zhou, JiChun; Guo, JuFeng; Teng, RongYue; Wang, QinChuan; Wang, Ji(王吉); Wei, Qun; Li, ZiDuo; Shen, JianGuo; Wang, LinBo. New utility of an old marker: serum low-density lipoprotein predicts histopathological response of neoadjuvant chemotherapy in locally advanced gastric cancer. OncoTargets and Therapy. 2016; 9:5041-5047.

◆成果奖励

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◆授权专利及转化  

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