胡韶山

◆导师基本情况

1.外科学博士，主任医师，博士生导师，神经外科主任

2.邮箱：shaoshanhu@126.com

3.指导专业：外科学神经外科

◆研究领域

脑胶质瘤的发生机制以及综合治疗、脑胶质瘤光动力靶向治疗、脑血管病显微外科治疗

◆主讲课程

外科学

◆教育和工作经历

1.教育经历：

1989-09-1995-06哈尔滨医科大学临床医学俄语系本科

1995-09-1998-06哈尔滨医科大学外科学硕士研究生

1998-09-2001-06哈尔滨医科大学外科学博士研究生

2.工作经历：

(1)2021-04至今,杭州医学院，附属人民医院(浙江省人民医院),神经外科,主任医师神经外科主任

(2)2008-10至2021-03,哈尔滨医科大学，附属第二医院,神经外科,主任医师

(3)2003-10至2008-09,哈尔滨医科大学，附属第二医院,神经外科,副主任医师

(4)2001-09至2003-09,哈尔滨医科大学，附属第二医院,神经外科,主治医师

(5)2001-07至2001-08,哈尔滨医科大学，附属第二医院,神经外科,医师

◆学术任职

1.现任中国抗癌协会肿瘤光动力治疗专业委员会主任委员兼外科学组组长；

2.中华医学会激光医学分会常务委员兼光动力诊治与肿瘤学组组长；

3.中国临床肿瘤学会肿瘤光动力治疗专家委员会副主任委员；

4.中国医师协会周围神经专业委员会常务委员；

5.中国卒中学会脑出血微创治疗分会常务委员；

6.中国医师协会脑胶质瘤专业委员会全国委员；

7.中国抗癌协会胶质瘤专业委员会全国委员；

8.中国抗癌协会理事会理事；

9.浙江省抗癌协会神经肿瘤专业委员会副主任委员；

10.浙江省医学会神经外科分会副主任委员；

11.浙江省医师协会脑胶质瘤专业委员会副主任委员；

12.浙江省心脑血管预防与控制专业委员会副主任委员；

13.浙江省医师协会神经外科医师分会常务委员；

14.浙江省卒中学会第二届理事会常务理事

◆主持教学科研项目

1.脑胶质瘤瘤周不均质性的相关研究（C-2021-QDJJ03）浙江省人民医院人才引进科研启动基金

2.2022年浙江省人民医院杰出领军人才（C-2022-YYJCLJRC01）浙江省人民医院人才培养工程

3.2023年度临床医技学科带头人培养（C-2023-XKDTR08）2023年度临床医技学科带头人培养

4.树突状细胞外泌体在脑胶质瘤光动力治疗中的抗肿瘤免疫机制研究浙江省卫生健康委员会

5.光动力对NHE1表达的影响及联合替莫唑胺抗鼠移植胶质瘤的相关研究（NO.61575058）国家自然科学基金

◆代表性论著

1.Gao X, Zhao X, Li J, Liu C, Li W, Zhao J, Li Z, Wang N, Wang F, Dong J, Yan X, Zhang J, Hu X, Jin J, Mang G, Ma R and Hu S. Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke. Cell Commun Signal. 2024, 22(1):50. 

2.Dong J, Wang F, Xu Y, Gao X, Zhao H, Zhang J, Wang N, Liu Z, Yan X, Jin J, Ji H, Cheng R, Wang L, Qiu Z and Hu S. Using mixed reality technique combines multimodal imaging signatures to adjuvant glioma photodynamic therapy. Front Med (Lausanne). 2023, 10:1171819.

3.Zhao H, Dong J, Zhang J, Wang N, Liu Z, Yan X, Wang F, Ji H and Hu S. Expression of intra-tumoral necrosis-associated cytokine pattern correlated with prognosis and immune status in glioma. Front Mol Neurosci. 2023, 16:1117237. 

4.Jin J, Wang F, Tian J, Zhao X, Dong J, Wang N, Liu Z, Zhao H, Li W, Mang G and Hu S. Neutrophil extracellular traps contribute to coagulopathy after traumatic brain injury. JCI Insight. 2023, 8(6):e141110. 

5.Dong J, Wang F, Gao X, Zhao H, Zhang J, Wang N, Liu Z, Yan X, Jin J, Ba Y, Ma S, Du J, Ji H and Hu S. Integrated analysis of genome-wide DNA methylation and cancer-associated fibroblasts identified prognostic biomarkers and immune checkpoint blockade in lower grade gliomas. Front Oncol. 2023, 12:977251. 

6.Wang F, Dong J, Zhang J, Zhao H, Wang N, Jin J, Yan X, Gao X, Liu H and Hu S. Rapid progression of subcutaneous glioblastoma: A case report and literature review. Front Oncol. 2023, 13:935944. 

7.Zhang J, Wang N, Wu J, Gao X, Zhao H, Liu Z, Yan X, Dong J, Wang F, Ba Y, Ma S, Jin J, Du J, Ji H and Hu S, 5-Methylcytosine Related LncRNAs Reveal Immune Characteristics, Predict Prognosis and Oncology Treatment Outcome in LowerGrade Gliomas. Front Immunol, 2022, 13:844778. 

8.Yan X, Wang N, Dong J, Wang F, Zhang J, Hu X, Zhao H, Gao X, Liu Z, Li Y and Hu S, A cuproptosis-related lncRNAs signature for prognosis, chemotherapy, and immune checkpoint blockade therapy of low-grade glioma. Front Mol Biosci, 2022, 9:966843. 

9.Yan X, Ji H, Liu Z, Ma S, Dong J, Jiang X, Hu X, Wang F, Zhao H, Jin J, Zhang J, Wang N, Du J and Hu S, Characterization of the Ferroptosis-Related Genes for Prognosis and Immune Infiltration in Low-Grade Glioma. Front Genet, 2022, 13:880864. 

10.Wu J, He J, Zhang J, Ji H, Wang N, Ma S, Yan X, Gao X, Du J, Liu Z and Hu S, Identification of EMT-Related Genes and Prognostic Signature With Significant Implications on Biological Properties and Oncology Treatment of Lower Grade Gliomas. Front Cell Dev Biol, 2022, 10:887693. 

11.Ma S, Wang F, Wang N, Jin J, Yan X, Wang L, Zheng X, Hu S and Du J, Extended Application of Genomic Selection to Screen Multi-Omics Data for the Development of Novel Pyroptosis-Immune Signatures and Predicting Immunotherapy of Glioma. Front Pharmacol, 2022, 13:893160. 

12.Ma S, Wang F, Wang N, Jin J, Ba Y, Ji H, Du J and Hu S, Multiomics Data Analysis and Identification of Immune-Related Prognostic Signatures With Potential Implications in Prognosis and Immune Checkpoint Blockade Therapy of Glioblastoma. Front Neurol, 2022, 13:886913. 

13.Ma S, Wang F, Dong J, Wang N, Tao S, Du J and Hu S, Inhibition of hypoxiainducible factor 1 by acriflavine renders glioblastoma sensitive for photodynamic therapy. J Photochem Photobiol B, 2022, 234:112537. 

14.Liu Z, Ji H, Fu W, Ma S, Zhao H, Wang F, Dong J, Yan X, Zhang J, Wang N, Wu J and Hu S, IGFBPs were associated with stemness, inflammation, extracellular matrix remodeling and poor prognosis of low-grade glioma. Front Endocrinol (Lausanne), 2022, 13:943300. 

15.Ji H, Liu Z, Wang N, Jin J, Zhang J, Dong J, Wang F, Yan X, Gong Q, Zhao H, Sun H, Li Y, Hu S and You C, Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas. Front Immunol, 2022, 13:970702. 

16.Dong J, Zhao H, Wang F, Jin J, Ji H, Yan X, Wang N, Zhang J and Hu S, Ferroptosis-Related Gene Contributes to Immunity, Stemness and Predicts Prognosis in Glioblastoma Multiforme. Front Neurol, 2022, 13:829926. 

17.Dong J, Wang F, Gao X, Zhao H, Zhang J, Wang N, Liu Z, Yan X, Jin J, Ba Y, Ma S, Du J, Ji H and Hu S, Integrated analysis of genome-wide DNA methylation and cancer-associated fibroblasts identified prognostic biomarkers and immune checkpoint blockade in lower grade gliomas. Front Oncol, 2022, 12:977251. 

18.Ma S, Ba Y, Ji H, Wang F, Du J and Hu S, Recognition of Tumor-Associated Antigens and Immune Subtypes in Glioma for mRNA Vaccine Development. Front Immunol, 2021, 12:738435. 

19.Ji H, Zhao H, Jin J, Liu Z, Gao X, Wang F, Dong J, Yan X, Zhang J, Wang N, Du J and Hu S, Novel Immune-Related Gene-Based Signature Characterizing an Inflamed Microenvironment Predicts Prognosis and Radiotherapy Efficacy in Glioblastoma. Front Genet, 2021, 12:736187. 

20.Ji H, Ba Y, Ma S, Hou K, Mi S, Gao X, Jin J, Gong Q, Liu T, Wang F, Liu Z, Li S, Du J and Hu S, Construction of Interferon-Gamma-Related Gene Signature to Characterize the Immune-Inflamed Phenotype of Glioblastoma and Predict Prognosis, Efficacy of Immunotherapy and Radiotherapy. Front Immunol, 2021, 12:729359. 

21.Hou K, Liu J, Du J, Mi S, Ma S, Ba Y, Ji H, Li B and Hu S, Dihydroartemisinin prompts amplification of photodynamic therapy-induced reactive oxygen species to exhaust Na/H exchanger 1-mediated glioma cells invasion and migration. J Photochem Photobiol B, 2021, 219:112192. 

22.Du J, Ji H, Ma S, Jin J, Mi S, Hou K, Dong J, Wang F, Zhang C, Li Y and Hu S, m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma. Brief Bioinform, 2021, 22: 

23.Zhou P, Li T, Jin J, Liu Y, Li B, Sun Q, Tian J, Zhao H, Liu Z, Ma S, Zhang S, Novakovic VA, Shi J and Hu S, Interactions between neutrophil extracellular traps and activated platelets enhance procoagulant activity in acute stroke patients with ICA occlusion. EBioMedicine, 2020, 53:102671. 

24.Du J, Yan X, Mi S, Li Y, Ji H, Hou K, Ma S, Ba Y, Zhou P, Chen L, Xie R and Hu S, Identification of Prognostic Model and Biomarkers for Cancer Stem Cell Characteristics in Glioblastoma by Network Analysis of Multi-Omics Data and Stemness Indices. Front Cell Dev Biol, 2020, 8:558961. 

25.Du J, Ji H, Jin J, Gao S, Yan X and Hu S, Pituitary adenoma secondary to primary hypothyroidism: Two case reports. Medicine (Baltimore), 2020, 99:e19222. 

Du J, Hou K, Mi S, Ji H, Ma S, Ba Y, Hu S, Xie R and Chen L, Malignant Evaluation and Clinical Prognostic Values of m6A RNA Methylation Regulators in Glioblastoma. Front Oncol, 2020, 10:208. 

26.Jia Y, Chen L, Chi D, Cong D, Zhou P, Jin J, Ji H, Liang B, Gao S and Hu S, Photodynamic therapy combined with temozolomide inhibits C6 glioma migration and invasion and promotes mitochondrial-associated apoptosis by inhibiting sodium-hydrogen exchanger isoform 1. Photodiagnosis Photodyn Ther, 2019, 26:405-412. 

27.Hu S, Yang Y, Jiang B, Su D, Zhang L, Huang Z and Zhang F, Treatment of condyloma acuminatum using the combination of laser ablation and ALA-PDT. Photodiagnosis Photodyn Ther, 2019, 25:193-196. 

28.Yao Z, Wang L, Wu X, Zhao L, Chi C, Guo L, Tong D, Yang X, Dong Z, Deng R, Novakovic VA, Thatte HS, Bi Y, Tian Y, Shi J, Zhou J, Kou J and Hu S, Enhanced Procoagulant Activity on Blood Cells after Acute Ischemic Stroke. Transl Stroke Res, 2017, 8:83-91. 

29.Chen L, Cong D, Li Y, Wang D, Li Q and Hu S, Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression. Ultrason Sonochem, 2017, 39:654- 661. 

30.人民卫生出版社 激光医学临床实践-光动力疗法与肿瘤分册（2024年），主编 

31.天津科学技术出版社，光动力疗法中国肿瘤整合诊治技术指南(CACA)（2023年），主编 

32.科学技术文献出版社：光动力治疗操作技术规范（2020年），副主编

◆成果奖励

1.2023年度发明创业奖创新奖（2023年7月），一等奖，新型抗肿瘤药物研发和临床应用关键技术；

2.黑龙江省科学技术奖（2021年12月），二等奖，高效抗癌诊疗材料的设计、性能协同增益和临床应用

3.黑龙江省高校科学技术奖（2020年12月），一等奖，高效抗癌诊疗材料的设计、性能协同增益和临床应用

◆授权专利及转化

1.2022SR1049774脑胶质瘤生发界面辅助决策系统V1.0计算机软件著作权

2.ZL202122835726.5用于细胞缺氧培养的装置实用新型专利