◆ 基本情况

姓名：贺瑞，口腔医学博士，副教授（硕士生导师）

邮箱：heruiminli@sina.com

专业：口腔医学

◆ 研究领域

口腔组织病理性矿化；口腔组织工程；口腔缺损修复；口腔生物材料

◆ 主讲课程

研究生课程：《口腔医学新进展》；《口腔专业英语》

本科生课程：《口腔修复学I》；《口腔修复学II》；《口腔材料学》；《口腔生物学》；《口腔医学导论》；《口腔医学新进展》；《口腔种植学》；《口腔实践技能培训修复模块》

◆ 主持教学科研项目和科研成果

◆ 教学科研项目

1. 浙江省医药卫生科技计划项目，PCL-Gel/PLA-Gel 纳米双纤维膜的制备及其在骨缺损中的实验研究 ，2024.01-2026.12

2. 杭州市医药卫生科技项目，龙脑抗菌3D打印硅基磷酸钙成骨支架的相关研究，

2024.4.30-2027.4.29

3. 浙江省医药卫生科技计划项目，慢性牙周炎与牙髓矿化相关性的影像学研究，

2021.01-2023.12；

4. 浙江省医药卫生科技计划项目，多功能碳纳米管基靶向载药体系的制备及其抗肿瘤的实验室研究，2016.01-2018.12

5. 杭州市科技计划引导项目，慢性牙周炎与牙髓矿化的相关性研究，2021.01-2023.12

6. 杭州市生物医药和健康产业发展扶持科技项目，羟基磷灰石-壳聚糖-明胶三联组支架的制备及其生物学应用研究，202201-2024.12，

7. 杭州市生物医药和健康产业发展扶持科技项目，数字化评估等技术在提高口腔修复效果中的应用与探索，2022.04-2025.03

8. 国家自然科学基金面上项目，牙龈卟啉单胞菌分泌牙龈素对动脉粥样硬化血管平滑肌细胞增殖的影响及其机制研究（参研）；

9. “十四五”研究生教育改革项目，基于 Workshop+CBL 模式培养口腔专硕研究生数字化临床实践能力，2023年

10. 省级一流本科课程，口腔修复学，2022年

11. 杭州市课程建设项目，口腔修复学，2014年

12. 杭州师范大学专业学位研究生课程教学案例库建设项目，口腔修复学新进展，2019年

◆ 科研成果

1. Hongzhe Fang, Peipei Wu, Cheng Qian, Yifan Gu, Lu Yu, Sheng Fang, Kailun Chen, Anna Qiu, Hongjie Huang, Qi Chen, Rui He*. Evaluation of mechanical and thermal stress in an endodontically treated cracked premolar with three restorative designs: 3D-finite element analysis. Journal of Prosthodontic Research. 2025, 1:1-9.

2. Lixia Xu, Ying Zhang, Shuqi Jin, Shuxin Luo, Kailun Chen, Sheng Fang, Liangjun Zhong, Jian Zhang*, Rui He*. Novel lignin α-O-4 derived hydrogen donors in CQ-based photoinitiating systems for dental resins. Scientific Reports. 2024, 14(1):16719.

3. Anna Qiu, Lixia Xu, Yuan Zhang, Kailun Chen, Sheng Fang, Ying Zhang, Liangjun Zhong, Rui He*. Digital-assisted multidisciplinary treatment for complex occlusal rehabilitation: an 18-month follow-up case report. BMC Oral Health. 2024, 24(1):818.

4. Zhuochen Zhang, Ying Zhang, Yabin Guo, Cheng Qian, Kailun Chen, Sheng Fang, Anna Qiu, Liangjun Zhong, Jian Zhang, Rui He*. Preparing gelatin-containing polycaprolactone / polylactic acid nanofibrous membranes for periodontal tissue regeneration using side-by-side electrospinning technology. Journal of Biomaterials Applications. 2024, 39(1):48-57.

5. Shuxin Luo, Lixia Xu, Zhuochen Zhang, Liangjun Zhong, Rui He*. Four-dimensional digital design to prediction of the real-time functional rehabilitation in the esthetic zone. Journal of Prosthetic Dentistry. 2023 Jun 8; S0022-3913 (23)00282-2.

6. Yifan Gu, Cheng Qian, Lu Yu, Hongzhe Fang, Jintao Wang, Peipei Wu, Liangjun Zhong, Kai Liu, Rui He*. Prognostic nomogram for patients with tongue squamous cell carcinoma: A SEER-based study. Oral Diseases. DOI: 10.1111/odi.14521.

7. Qiushuo Sun, Lu Yu, Zhuocheng Zhang, Cheng Qian, Hongzhe Fang, Jintao Wang, Peipei Wu, Xiaojing Zhu, Jian Zhang, Liangjun Zhong, Rui He*. Novel gelatin/carboxymethyl chitosan/nano-hydroxyapatite/β-tricalcium phosphate biomimetic nanocomposite scaffold for bone tissue engineering applications. Frontiers in Chemistry. DOI: 10.3389/fchem.2022.958420.

8. Lingling Xiang, Botao Wang, Yuan Zhang, Jintao Wang, Peipei Wu, Jian Zhang, Liangjun Zhong, Rui He*. Cone beam computed tomography assessment of the prevalence and association of pulp calcification with periodontitis. Odontology. DOI:10.1007/s10266-022-00733-5.

9. Rui He, Conrad Chou, Ling Chen, Marshall Stoller, Misun Kang, Sunita P Ho*. Insights into Pulp Biomineralization in Human Teeth. Frontiers in Dental Medicine, doi: 10.3389/fdmed.2022.883336.

10. Feifei Yu; Wenzhou Shen; Yaling Sun; Yilei Liao; Shuqi Jin; Xiunan Lu; Rui He*; Liangjun Zhong*; Guofu Zhong; Jian Zhang*; Ruthenium-catalyzed C–H amination of aroylsilanes, Organic & Biomolecular Chemistry, 2021, 19(28): 6313-6321.

11. Yazhou Wang, Yuhang Zhu, Lixia Xu, Rui He*, Jian Zhang*. Recent Advances in Geminal-Group-Directed Alkenyl C–H Functionalization. Chinese Journal of Organic Chemistry. DOI: 10.6023/cjoc202202028

12. Lixia Xu, Shuxin Luo, Botao Wang, Lingling Xiang, Zhuochen Zhang, Rui He*. One Case of Occlusal Reconstruction with Electronic Face Bow. IADR/APR General Session & Exhibition, China, 2022.6.20-25.

13. Rui He; Ling Chen; Misun Kang; Marshall Stoller; Sunita. P. Ho*, Insights into Biomineralization of Pulp in a Human Tooth, AADR/CADR General Session& Exhibition, Fort Lauderdale, USA, 2018.03.21 -24.

14. 贺瑞，张远，丁成，张鹏涛，吴周燕，连文海，钟良军.口腔各科诊疗过程中新型冠状病毒的防护.健康研究, 2020,40(3):264-267.

15. 贺瑞, 张远, 王进涛, 等.在口腔修复实践技能培训特色课程中应用标准化病人.中国高等医学教育.2020,4:103-104.

16. 童子安,林哲臻,徐丽霞,王栎程,俞杰南,钟良军,贺瑞*.杭州师范大学学生口腔健康教育效果评价. 中国学校卫生杂志. 2017,38(5):754-756.

17. Putu Ustriyana; Rui He; Sudarshan Srirangapatanam; Jasper Chang; Sheeler T Arman; Sukhman deep Sidhu; Bo Wang; Misun Kang; Sunita P Ho ; Food hardness can regulate orthodontic tooth movement in mice, Journal of Periodontal Res, 2022,57(2):269-283.

18. Lynn Yang; Misun Kang; Rui He; Bo Meng; Arvin Pal; Ling Chen; Andrew H. Jheon; Sunita P. Ho*, Microanatomical changes and biomolecular expression at the PDL-entheses during experimental tooth movement, Journal of Periodontal Research, 2018, 9:1-8.