涂建飞

◆  导师基本情况

浙江大学医学院博士，主任医师三级岗，硕士研究生导师，丽水市中心医院肿瘤中心主任，肿瘤片组组长，丽水市创新学科（胸腹部肿瘤综合诊治）带头人，丽水市胸腹部肿瘤综合诊治重点实验室主任

邮箱：jianfei1133@163.com

指导专业：肿瘤学

◆  研究领域

1.恶性肿瘤介入综合临床与基础研究

2.恶性肿瘤免疫微环境研究

3.肿瘤多模态组学

4.介入新材料、新器械基础研发

◆  主讲课程

肿瘤学进展

◆  教育和工作经历

学习经历：

2006年毕业于苏州大学，获影像医学与核医学硕士学位

2025年毕业于浙江大学，获生物物理学博士学位

工作经历：

1996在丽水市中心医院工作至今

2014.06-2014.09加拿大麦吉尔大学附属医院介入科进修

2015年9月赴日本IGT介入诊所交流学习

2016.09-2016.10到美国南加州大学附属keck医院，介入科学习

2019年获主任医师聘书

◆  学术简介

长期从事肿瘤精准影像诊断及介入治疗学的临床和基础研究工作，作为项目负责人荣获浙江省科技进步三等奖1项，市厅级奖项6项。鉴于申请人长期围绕肿瘤精准影像学诊断以及介入治疗学卓有成效的研究工作，已荣获“浙江省卫生高层次创新人才”、“浙江省151人才工程第二层次培养人员” 、“浙江省医坛新秀培养对象”等荣誉称号。

◆  主持教学科研项目

1.国家自然科学基金委员会, 面上项目, 82072026, 基于靶向递药纳米结构的溶蚀性可视化栓塞微球的级联肝癌介入治疗研究, 2021-01-01 至 2024-12-31, 55万元, 在研, 参与

2.浙江省自然科学基金委员会, 探索项目, LY23H180003, 肿瘤穿透肽 iRGD 修饰的新型钆基肿瘤靶向对比剂的成像效能及作用机制研究, 2023-01 至 2025-12, 10万元, 在研, 主持

3.国家卫生健康委员会, 浙江省医药卫生重大科技计划重点项目, WKJ-ZJ-1932, 外泌体源miR-210通过自噬调控细胞表型转化引发缺氧诱导肝细胞癌肺转移的临床与基础研究, 2019-01 至 2020-12, 15万元, 结题,主持

4.浙江省科技社会厅公益性项目、LGF18H220001, 射频消融为核心的中晚期肝癌临床治疗策略优化研究、201801-202012、10万元、在研、主持。

◆  代表性论著

1.Jianfei Tu1 , Zhongzhi Jia2 , Binyan Zhong3 , Bin Shen4 , Guodong Zhang5 , Dengke Zhang1 , Haipeng Yu6 , Yiping Chen7 , Xi Liu8 , Liming Wang9 , Gaojun Teng10,11,12,13,14, Sen Jiang15, Jiansong Ji1,16, Clinical Guidelines Committee of Chinese College of Interventionalists Bronchial artery embolization for hemoptysis: a consensus statement by the Chinese College of Interventionalists,2025

2.Linqiang Lai; Fenfen Xu; Dengke Zhang; Jie Chen; Xihui Ying; Li Chen; Jiahao Wu; JingjingSong; Weiwen Li; Jiansong Ji;Jianfei Tu; Bronchial arterial chemoembolization with Drug-Elutingbeads plus sequential chemotherapy for the treatment of stage III and IV lung squamous cell carcinoma, European Journal of Radiology, 2024

3.Xiaoju Guo#, Xiaoxiao Chen#, Jiayi Ding, Feng Zhang, Shunyang Chen, Xin Hu, Shiji Fang, Lin Shen, Chenying Lu, Zhongwei Zhao,Jianfei Tu, Gaofeng Shu∗, Minjiang Chen∗, Jiansong Ji∗Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy 2024

4.Shiji Fang#, Liyun Zheng#, Gaofeng Shu#, Chen Xiaoxiao, Xiaoju Guo, Yiming Ding, Wenjing Yang, Jiale Chen, Zhongwei Zhao,Jianfei Tu, Minjiang Chen*, Jiansong Ji* Multiple Immunomodulatory Strategies Based on Targeted Regulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Immune Homeostasis against Hepatocellular Carcinoma2024，8811-8826

5.Jianfei Tu; Qing Liu; Shengye You; Zhuojun Meng; Shiji Fang; Binhong Yu; Xumin Chen; Yu Zhou; Lulu Zeng; Andreas Herrmann; Gang Chen; Jianliang Shen; Lifei Zheng; Jiansong Ji; Recombinant supercharged polypeptides for safe and efficient heparin neutralization, Biomaterials Science, 2023, 11(16): 5533-5539

6.Zhongwei Zhao; Jingjing Song; Bufu Tang; Shiji Fang; Dengke Zhang; Liyun Zheng; Fazong Wu; Yang Gao; Chunmiao Chen; Xianghua Hu; Qiaoyou Weng; Yang Yang;Jianfei Tu; Jiansong Ji ;CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway, Journal of Experimental & Clinical Cancer Research, 2020, 39(1): 259

7.Shiji Fang#, Liyun Zheng#, Xiaoxiao Chen, Xiaoju Guo, Yiming Ding, Ji Ma, Jiayi Ding, Weiqian Chen, Yang Yang, Minjiang Chen, Zhongwei Zhao,Jianfei Tu, Jiansong Ji*MEX3A determines in vivo hepatocellular carcinoma progression and induces resistance to sorafenib in a Hippo‑dependent way2023，1500-1518

8.Chunli Kong#, Linqiang Lai#, Xiaofeng Jin#, Weiyue Chen, Jiayi Ding, Liyun Zheng, Dengke Zhang, Xihui Ying, Xiaoxiao Chen, Minjiang Chen,Jianfei Tu, Jiansong Ji*Machine Learning Classifier for Preoperative Prediction of Early Recurrence After Bronchial Arterial Chemoembolization Treatment in Lung Cancer Patients2023，2880-2893

9.Bufu Tang#, Yajie Wang#, Jinyu Zhu#, Jingjing Song, Shiji Fang, Qiaoyou Weng, Yang Yang,Jianfei Tu, Zhongwei Zhao, Minjiang Chen, Min Xu, Weiqian Chen*, Jiansong Ji* TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC 

10.Minjiang Chen#, Xiaoju Guo#, Lin Shen, Jiayi Ding, Junchao Yu, Xiaoxiao Chen, Fazong Wu,Jianfei Tu, Zhongwei Zhao, Mitsutoshi Nakajima, Jingjing Song*, Gaofeng Shu*, Jiansong Ji*Monodisperse CaCO3-loaded gelatin microspheres for reversing lactic acid-induced chemotherapy resistance during TACE treatment2023

11.Shiji Fang#, Liyun Zheng#, Lin Shen, Yanping Su, Jiayi Ding, Weiyue Chen, Xiaoxiao Chen, Weiqian Chen, Gaofeng Shu, Minjiang Chen, Zhongwei Zhao, Jianfei Tu*, Jiansong Ji*Inactivation of KDM5A suppresses growth and enhances chemosensitivity in liver cancer by modulating ROCK1/PTEN/AKT pathway2023

12.Weiwen Liu#,Jianfei Tu#, Xihui Ying, Zhengju Chen, Yunbing Wang*Postoperative survival of extrahepatic and intrahepatic cholangiocarcinoma after surgery: a population-based cohort2022，e049789

13.Haidong Zhu#, Xiao Li#, Jiansong Ji, Ming Huang, Guoliang Shao, Jian Lu, Xuya Zhao, HailLiang Li, Zhengqiang Yang, Jianfei Tu, Jinmei Zhou, Chuhui Zeng, Gaojun Teng* TACE with dicycloplatin in patients with unresectable hepatocellular carcinoma: a multicenter randomized phase II trial 2022，7335-7343

14.Nannan Zhang#, Gaofeng Shu#, Enqi Qiao, Xiaoling Xu, Lin Shen, Chenying Lu, Weiqian Chen, Shiji Fang, Yang Yang, Jingjing Song, Zhongwei Zhao,Jianfei Tu, Min Xu, Minjiang Chen*, Yongzhong Du*, Jiansong Ji*

DNA-Functionalized Liposomes In Vivo Fusion for NIR-II/MRI Guided Pretargeted Ferroptosis Therapy of Metastatic Breast Cancer 2022，20603-20615

15.Minjiang Chen#, Jie Li#, Gaofeng Shu#, Lin Shen, Enqi Qiao, Nannan Zhang, Shiji Fang, Xiaoxiao Chen, Zhongwei Zhao, Jianfei Tu, Jingjing Song*, Yongzhong Du*, Jiansong Ji* Homogenous multifunctional microspheres induce ferroptosis to promote the anti-hepatocarcinoma effect of chemoembolization 2022，179

16.Nannan Zhang#, Gaofeng Shu#, Lin Shen, Jiayi Ding, Enqi Qiao, Shiji Fang, Jingjing Song, Yang Yang, Zhongwei Zhao, Chenying Lu,Jianfei Tu, Min Xu, Yongzhong Du*, Minjiang Chen*, Jiansong Ji*Biomimetic mesoporous polydopamine nanoparticles for MRI guided photothermal-enhanced synergistic cascade chemodynamic cancer therapy 2022，5262-5272

17.Dengke Zhang#, Fazong Wu#, Jingjing Song#, Miaomiao Meng, Xiaoxi Fan, Chenying Lu, Qiaoyou Weng, Shiji Fang, Liyun Zheng, Bufu Tang, Yang Yang,Jianfei Tu, Min Xu, Zhongwei Zhao*, Jiansong Ji* A role for the NPM1/PTPN14/YAP axis in mediating hypoxia-induced chemoresistance to sorafenib in hepatocellular carcinoma 2022，65

18.Jianfei Tu; Zhongwei Zhao; Min Xu; Minjiang Chen; Qiaoyou Weng; Jiansong Ji ; LINC00460 promotes hepatocellular carcinoma development through sponging miR-485-5p to up-regulate PAK1, Biomedicine & Pharmacotherapy, 2019, 118: 109213

19.Chunli Kong; Zhongwei Zhao; Weiyue Chen; Xiuling Lv; Gaofeng Shu; Miaoqing Ye; Jingjing Song; Xihui Ying; Qiaoyou Weng; Wei Weng; Shiji Fang; Minjiang Chen; Jianfei Tu; Jiansong Ji ;Prediction of tumor response via a pretreatment MRI radiomics-based nomogram in HCC treated with TACE, European Radiology, 2021, 31(10): 7500-7511

◆ 成果奖励

1,.原始创新型纳秒刀精准消融肝癌的研发及临床应用，浙江省转化医学学会，特等奖

2.放射免疫联合射频波消融序贯应用在中晚期肝癌中的临床研究，浙江省人民政府，三等奖 

3.干扰素联合肝动脉化疗栓塞对肝癌微环境影响的实验研究， 丽水市人民政府， 二等奖

4.干扰素联合肝动脉化疗栓塞对肝癌微环境影响的实验研究，浙江省卫生和计划生育委员会，三等奖 

5.原发性肝癌早期筛检及介入治疗优化的临床应用研究，浙江省人民政府，二等奖

◆ 参编专著

1.《CT诊断证明》，编者

2.《中华医学影像案例解析宝典》，编委

3.《肠梗阻影像学》，编者