何登伟

◆  导师基本情况

丽水市中心医院院长，主任医师，硕士生导师

邮箱：Hedw_spine@163.com

指导专业：外科学

◆  研究领域

骨科脊柱外科临床、骨代谢、肌少症

◆  主讲课程

1. 《骨科学进展》——胸腰椎骨折外科治疗进展

2. 《临床科研设计与论文写作》——科研选题

3. 《外科学进展》——骨科学进展

◆  教育和工作经历

学习经历：

1989-09 至 1994-07, 浙江大学, 临床医学系, 学士

2002-09 至 2007-06, 温州医学院, 骨外科学, 硕士

2014-09 至 2019-03, 浙江大学, 骨外科学, 博士

工作经历：

1994-08 至 2000-12, 温州医科大学, 附属第五医院, 医师

2001-01 至 2005-12, 温州医科大学, 附属第五医院, 主治医师

2006-01 至 2010-12, 温州医科大学, 附属第五医院, 副主任医师

2011-01 至今, 温州医科大学, 附属第五医院, 主任医师

◆  学术简介

长期从事脊柱外科工作，在脊柱外科微创技术领域中取得累累硕果。较早地开展了颈椎内镜技术、腰椎间孔镜技术、腰椎镜下融合技术、腰椎斜外侧融合OLIF技术。另外诸如脊柱结核、脊柱化脓性感染、老年骨质疏松症的微创手术也创新性地走在省内外同行的前列。 同时也注重医学科学研究，以第一作者/通讯作者身份在《European Spine Journal》等杂志上发表SCI论文40余篇。主持科研成果荣获省科技进步奖、省医药卫生科技奖、丽水市科技进步奖。研发和设计了一套新型脊柱微创内固定系统（Can-Help系统）并成功实施成果转化，授权浙江科惠医疗器械有限公司生产，顺利进入临床应用阶段，已经顺利在省内外各家医院临床使用。

◆ 主持教学科研项目

 1. 2024-2026，浙江省省医药卫生科技项目（2024KY569）肉碱干预Nrf2氧化应激抑制破骨细胞分化改善骨质疏松的机制研究

2.2021-2023，省重点研发计划项目（2021C03194）肌肉骨骼系统疾病诊治新技术研究-经腰大肌前方入路的胸腰椎骨折微创前路重建技术的建立和优化及其临床应用研究

3.2018-2020，丽水市重点学科研究项目（2017ZDXK06）微创内固定和椎间孔镜治疗化脓性脊柱炎的临床对照研究

4.2017-2019年，浙江省自然科学基金（LY17C100002）老年骨质疏松脊柱骨折多米诺效应的生物力学动力学机制分析

5. 2016-2018年，浙江省科技厅公益项目（2016C33245）基于脊柱稳定性的Kummell病临床分型探讨及其微创治疗策略优化

6. 2016-2018年，浙江省医药卫生科技项目（2016KYA200）Kummell病继发脊柱节段不稳的临床意义及其微创治疗的策略优化

7. 2014-2016年，浙江省医药卫生科技项目（2014KYB315）老年骨质疏松脊柱骨折多米诺效应的生物力学动力学机制及最优化预防策略

8. 2015-2018年，国家自然科学基金（31471146）活体数字人脊柱脊髓与脑脊液系统生物力学平台构建关键技术及其在数字外科的应用

9. 2013-2015年，卫生部专项课题（W2013ZT183）高粘度骨水泥预防椎体成形术后伤椎再骨折的临床研究

10.2011-2015年，浙江省科技厅公益项目（2011C33026）胸腰椎骨折术后迟发性后凸畸形的预防及生物力学研究

11.2008-2010年，浙江省医药卫生科技项目（2008A170）关节突联合棘突间植骨融合预防胸腰椎骨折术后矫正丢失的临床研究和三维有限元分析

12.2011-2014年，丽 水 市 科 技 计 划 项 目，脊柱微创内固定系统的研发和临床应用研究，排名第13. 2013-2016年，国家自然科学基金（81271663 ）活体数字人随机生物力学模型试验与临床随机试验循证支撑的关节脊柱手术优化策略

13.2010-2013年，国家自然科学基金（30970702）下腰椎棘突间动态稳定内固定的生物力学机制研究

◆  代表性论著

1.Mei L, Sang W, He D, et al.. Small molecule inhibitor RepSox prevented ovariectomy-induced osteoporosis by suppressing osteoclast differentiation and bone resorption. J Cell Physiol. 2018 Dec;233(12):9724-9738.

2.Zheng L, Gao J, He D. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway. FASEB J. 2019 Jun;33(6):7667-7683.

3.Jin K, Zheng L, He D. Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signaling pathway. Biochem Pharmacol. 2021 Oct;192:114734. 

4.Pan W, Zheng L, Gao J, et al. SIS3 suppresses osteoclastogenesis and ameliorates bone loss in ovariectomized mice by modulating Nox4-dependent reactive oxygen species. Biochem Pharmacol. 2022;195:114846. 

5.Pan B, Zheng L, Fang J, et al. Azilsartan Suppresses Osteoclastogenesis and Ameliorates Ovariectomy-Induced Osteoporosis by Inhibiting Reactive Oxygen Species Production and Activating Nrf2 Signaling. Front Pharmacol. 2021;12:774709. Published 2021 Nov 26. doi:10.3389/fphar.2021.774709

6.Pan B, Zheng L, Liu S, et al. MiR-148a deletion protects from bone loss in physiological and estrogen-deficient mice by targeting NRP1. Cell Death Discov. 2022;8(1):470.

7.Yang T, Liu S, Ma H, et al. Carnitine functions as an enhancer of NRF2 to inhibit osteoclastogenesis via regulating macrophage polarization in osteoporosis. Free Radic Biol Med. 2024;213:174-189. doi:10.1016/j.freeradbiomed.2024.01.017

8.Ni KN, Ye L, Zhang YJ, et al. Formononetin improves the inflammatory response and bone destruction in knee joint lesions by regulating the NF-kB and MAPK signaling pathways [published online ahead of print, 2023 Apr 1]. Phytother Res. 2023;10.1002/ptr.7810. doi:10.1002/ptr.7810

9.Zhang Y, Zheng L, Fang J, et al. Macrophage migration inhibitory factor (MIF) promotes intervertebral disc degeneration through the NF-κB pathway, and the MIF inhibitor CPSI-1306 alleviates intervertebral disc degeneration in a mouse model. FASEB J. 2023;37(12):e23303. doi:10.1096/fj.202301441R

10.Zheng L, Fan S, He D. Primary chondrocyte exosomes mediate osteoarthritis progression by regulating mitochondrion and immune reactivity. Nanomedicine (Lond). 2019 Dec;14(24):3193-3212. 

11.Overexpression of miR-148a-3p inhibits extracellular matrix degradation and alleviates IL-1β-induced intervertebral disc degeneration. Iranian Journal of Basic Medical Sciences

12.Yang T, Ma H, Lai H, et al. Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway. Eur J Pharmacol. 2024;965:176326. doi:10.1016/j.ejphar.2024.176326

13.He D, Gao J, Fan S. TGF β inhibitor RepSox suppresses osteosarcoma via the JNK/Smad3 signaling pathway. Int J Oncol. 2021 Nov;59(5):84. 

14.何登伟，吴立军，池永龙. 双侧关节突联合棘突间植骨融合预防胸腰椎骨折术后矫正丢失的三维有限元分析. 医用生物力学, 2009, 24(3): 193-199. 

15.何登伟, 朱烨, 俞伟杨, 朱科军, 任少君, 吴立军. 伴前、中柱压缩的隐匿性胸腰椎屈曲牵张型骨折. 中华创伤杂志, 2010, 26(3): 217-220.

16.Dengwei He, Lijun Wu, Yonglong Chi, Shizhen Zhong. Facet joint plus interspinous process graft fusion to prevent postoperative late correction loss in thoracolumbar fractures with disc damage: finite element analysis and small clinical trials. Clinical Biomechanics, 2011, 26: 229-237. 

17.Dengwei He, Lijun Wu, Xiaoyong Sheng, et al. Internal fixation with percutaneous kyphoplasty compared with simple percutaneous kyphoplasty for thoracolumbar burst fractures in elderly patients: a prospective randomized controlled trial. European Spine Journal,2013, 22: 2256-2263.

18.何登伟，盛孝永，朱烨，等. 经皮椎体后凸成形术与联合内固定治疗老年胸腰椎骨质疏松性A3型骨折.中华骨科杂志，2013，33（12）：1183-1190

19.朱科军，何登伟(通讯作者)，盛孝勇，等.微创内固定结合经皮椎体后凸成形术治疗老年胸腰椎爆裂骨折.中华创伤杂志，2013,29（9）:849-852

20.何登伟，朱烨，俞伟杨，刘飞俊，黄文君，盛孝永，吴立军.棘突间H型植骨融合预防胸腰椎骨折术后迟发后凸畸形.中华创伤杂志，2014,30（2）：112-117 

21.黄文君，何登伟(通讯作者)，李方财，等.两种微创椎弓根螺钉系统治疗胸腰椎骨折的比较研究.中华创伤骨科杂志,2014,16(6):470-474

22.Yu WY, He DW. Current trends in spinal cord injury repair. Eur Rev Med Pharmacol Sci. 2015 Sep;19(18):3340-4.

23.He DW, Huang WJ, Sheng XY, Wu LJ, Fan SW. Atlantoaxial Joint Interlocking Following Type II Odontoid Fracture Associated with Posterolateral Atlantoaxial Dislocation: a Case Report and Review of Published Reports. Orthop Surg. 2016 Aug;8(3):405-10. 

24.Jian Chen, Dengwei He,Ursolic acid protects MC3T3-E1 cells against dexamethasone-mediated apoptosis, ROS generation and inflammation through activation of IGF-1.Int J Clin Exp Med 2016;9(12):23019-23030.

25.He D, Yu W, Chen Z, Li L, Zhu K, Fan S. Pathogenesis of the intravertebral vacuum of Kümmell's disease. Exp Ther Med. 2016 Aug;12(2):879-882. 

26.KEJUN ZHU,DENGWEI HE(Corresponding author).Intradural extramedullary capillary hemangioma: A case report and review of the literature.Oncology Letters.2016, 11: 2896-2898. 

27.Chao Lou, Guangheng Xiang, Dengwei He(Co-corresponding author).Menopause is associated with articular cartilage degeneration: a clinical study of knee joint in 860 women.Menopause.2016,23(11):1239-1246. 

28.Yu WY, Lou C, Liu FJ, He DW. Clinical efficacy of one stage posterior debridement joint graft fixation for lumbar vertebral fractures in spinal tuberculosis patients with compression. Eur Rev Med Pharmacol Sci. 2016 Jul;20(15):3161-7. 

29.Chao Lou, Dengwei He (Corresponding Author). Association between menopause and lumbar disc degeneration: an MRI study of 1,566 women and 1,382 men. Menopause. 2017 Oct;24(10):1136-1144.

30.李良辰,何登伟,梅良伟.胸腰椎陈旧性骨折继发后凸畸形致脊柱矢状位生理曲度改变的影像学研究[J].中华创伤杂志,2017,33(06):500-504.

31.Dengwei He,Kejun Zhu(Corresponding Author).Anterior reconstruction versus posterior osteotomy in treating Kümmell's disease with neurological defificits: A systematic review.Acta Orthopaedica et Traumatologica Turcica.(2018) 1-6

32.Dengwei He(responding Author)Titanium mesh bone grafting combined with pedicle screw internal fifixation for treatment of Kummell disease with cord compression A case report and literature review.Medicine (2018) 97:36(e12183) 

33.Zhong-you Zeng , Zhao-wan Xu, MD , Deng-wei He(共一)Complications and Prevention Strategies of Oblique Lateral Interbody Fusion Technique.Orthopaedic Surgery 2018;10:98–106

34.He D, Lou C, Yu W，et al. Cement Distribution Patterns Are Associated with Recompression in Cemented Vertebrae After Percutaneous Vertebroplasty: A Retrospective Study. World Neurosurg. 2018 Dec;120:e1-e7. 

35.Yu WY, Zhu KJ, Li QP, Lou C, He DW. Successful medical drainage and surgical treatment for vertebral osteomyelitis and bilateral psoas abscess with gas formation caused by klebsiella pneumoniae in a diabetic patient. Rev Assoc Med Bras (1992). 2019 Jun 3;65(5):678-681. 

36.Lou C, Yu W, Chen Z, Gao J, Liu F, He D. Short-term outcomes of percutaneous pedicle screw fixation combined with vertebroplasty: A minimally invasive treatment for Kümmell's disease with intravertebral instability. Acta Orthop Traumatol Turc. 2020 Nov;54(6):627-633. 

37.楼超,刘飞俊,何登伟.经皮内镜下切除术联合斜外侧椎间融合术治疗合并间盘脱出的腰椎退行性疾病[J].中华骨科杂志,2020(08):507-508-509-510-511-512-513-514.

38.刘飞俊,楼超,何登伟.经皮后路内固定联合经皮椎体成形术治疗Kümmell病继发节段不稳定的短期疗效[J].中华创伤杂志,2020,36(05):414-420.

39.Chen Z, Lou C, He D. Comparison of Intravertebral Clefts between Kümmell Disease and Acute Osteoporotic Vertebral Compression Fracture: A Radiological Study. Orthop Surg. 2021 Oct;13(7):1979-1986. 

40.Wu Z, Chen H, He D. Effect of TIMP2/TIMP3 genes on the risk of osteosarcoma in Zhejiang population. Medicine (Baltimore). 2021 Mar 19;100(11):e24818. 

41.Zhu K, He D. Transforaminal percutaneous endoscopic discectomy for symptomatic gas-filled discal cysts-report of three cases and literature review. J Orthop Surg Res. 2021 Apr 13;16(1):251. 

42.Pan B, Yu W, Lou C, Gao J, Huang W, He D. Comparison of mini-open, anteroinferior psoas approach and mini-open, direct lateral transpsoas approach for lumbar burst fractures: A retrospective cohort study. Front Surg. 2022;9:995410. 

43.楼超,俞伟杨,陈剑,何登伟.经皮椎间孔入路内镜下治疗腰椎融合术后邻椎腰椎间盘突出症[J].中国骨伤,2022,35(05):448-453.

◆  成果奖励

1.2011，关节突联合棘突间植骨融合预防胸腰椎骨折术后矫正丢失的临床研究和三维有限元分析，省医药卫生科技进步奖，三等奖

2.2012，关节突联合棘突间植骨融合预防胸腰椎骨折术后矫正丢失的临床研究和三维有限元分析，丽水市科技进步奖，二等奖

3.2014，胸腰椎骨折内固定系统的研发和临床应用研究 浙江省科技进步奖，三等奖

4.2014，脊柱微创内固定系统的研发和临床应用研究，浙江省医药卫生科技奖，二等奖

5.2016，胸腰椎骨折术后迟发性后凸畸形的预防及生物力学研究，丽水市科技进步奖，三等奖

◆  参编专著

1.《胸腰椎骨折》/ 科学出版社，ISBN 9787030789266