裘五四

◆ 导师基本情况

博士，副教授，副主任医师，硕士生导师

邮箱：shihai954@163.com

指导专业：外科学

◆ 研究领域

1. 神经损伤临床基础，脑血管疾病、神经肿瘤的微创手术治疗，昏迷病人促醒

2. 危急重症疾病（创伤、神经损伤）的基础和临床

◆ 主讲课程

外科学

◆ 教育和工作经历

学习经历：

1998.09～2001.07 温州医科大学医学学士

2002.07～2007.08 浙江大学医学院硕博

工作经历：

1994.07～2002.08  杭州医学高等专科学校实验师

2007.08～      杭州师范大学临床医学院副教授，附属医院神经外科副主任医师

◆ 学术简介

目前为浙江省医师协会脑胶质瘤专委会委员、浙江省中西医结合协会神经外科分会委员、杭州医学会神经外科分会秘书长及委员。研究方向为重型颅脑损伤、神经肿瘤与脑血管病的微创手术治疗、长期昏迷病人促醒诊疗，特别对神经保护的临床基础、创伤评分、神经监护有专长。承担省级等科研课题17项，获省市级科研奖6项，发表医学论文42篇（其中SCI论文24篇），入选杭州市“131 第二层次人才”，任AMS,Clinical Neurology and Neurosurgery, Critical Care等杂志审稿专家，曾应邀作为 Invited Speaker赴国外参加国际专业会议上讲座10次。共同主编《神经系统疾病危重症诊疗与监护》，共同副主编《实用神经外科重症监护重点与难点》、《Structure and Function of DTI-based White Matter Fiber Bundles》，参与编写《神经外科危急重症诊治指南》。获得杭州市131人才等多项荣誉。Archives of Medical Science, World Journal of Pediatrics, Clinical Neurology and Neurosurgery, Critical Care，Journal of Critical Care, World Journal of Gastroenterology, Journal of Anesthesialogy and Clinical Science(JACS)等杂志审稿人。

◆ 主持教学科研项目

1. 基于MM技术探索颅内压分层管理理念指导下EVD-LP治疗sIVH的临床研究 杭州市医药卫生科技项目  A20251639

2. 颅内压监测下安宫牛黄丸联合EVD-LP治疗重度脑室出血的临床研究 浙江省医学会临床科研基金 2021ZYC A80

3. 人可溶性TRAIL的基因克隆及其靶向治疗胶质瘤干细胞的实验研究 浙江省省自然基金 Y2080913

4. 选择性亚低温治疗大鼠脑外伤后Fas/Fas-L基因表达的影响  杭州市卫生局项目2006B017

5. 大骨瓣减压术联合选择性亚低温治疗脑外伤的实验研究 杭州市市卫生局项目 2007A011

6. 亚低温治疗对重型颅骨损伤患者大脑半球Pbto2梯度的影响 杭州市卫生局项目 2010A013

7. 院前亚低温治疗重型颅脑损伤的应用研究 杭州市科技局项目 20120533Q22

8. hsTRAIL基因抑制人类胶质瘤干细胞增值作用及其机制研究 浙江省卫生厅2014RCA023

9. 脑积水患者腰大池脑脊液外引流治疗前后无创性静息态脑rCBF的fMRI研究杭州市卫生局项目 2014A19

◆ 代表性论著

1.Intracranial pressure management in severe intraventricular hemorrhage: A minireview. World J Crit Care Med 2026; 15(1): 115169.(一作)

2. Gamma-glutamyl transferase as a redox-gatekeeper biomarker for pancreatic cystic neoplasms: A concise roadmap from epidemiology to bedside.World J Gastroenterol. 2026 ;32(3):114948. (SCI 通讯作者)

3. Paradox of protection: Re-examining cannabis use disorder in sepsis outcomes among cancer patients.World J Crit Care Med. 2025;9;14(4):106085.(一作)

4. Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database.Intensive Care Med. 2025;51(3):518-528.(SCI 共作)

5. Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.Clin Microbiol Infect. 2024;30(12):1559-1568.(SCI 共作)

6. Protective effects of Electroacupuncture on patients with spontaneous severe intraventricular hemorrhage.Brain Stimulation.2024.12.1134. (SCI 一作)

7. Presentation, management, and outcomes of older compared to younger adults with hospital-acquired bloodstream infections in the intensive care unit: a multicenter cohort study.Infection. 2024;52(6):2435-2443.(SCI 共作)

8. The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections.Intensive Care Med. 2024 ;50(6):873-889.(SCI 共作)

9.Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.Intensive Care Med. 2023;49(2):178-190.(SCI 共作)

10. Pre-hospital mild therapeutic hypothermia for patients with severe traumatic brain injury.Brain Inj. 2022;36(1):72-76. (SCI 一作)

11. IMP-ICDX: an injury mortality prediction based on ICD-10-CM codes.World J Emerg Surg. 2019 ;14:46. (SCI 共作)

12. Tumor Tissue Detection using Blood-Oxygen-Level-Dependent Functional MRI based on Independent Component Analysis.Sci Rep. 2018;8(1):1223.(SCI 共作)

13. Application of pulsed arterial resuscitation in a rabbit model of hemorrhagic shock.Ulus Travma Acil Cerrahi Derg. 2017;23(6):445-451. (SCI 通讯作者)

14. Potential mechanisms of microRNA-129-5p in inhibiting cell processes including viability, proliferation, migration and invasiveness of glioblastoma cells U87 through targeting FNDC3B.Biomed Pharmacother. 2017;87:405-411. (SCI 共作)

15. Tangent function transformation of the Abbreviated Injury Scale improves accuracy and simplifies scoring.Arch Med Sci. 2015;11(1):130-6. (SCI 通讯作者)

16. Changes in intracranial pressure gradients between the cerebral hemispheres in patients with intracerebral hematomas in one cerebral hemisphere.BMC Anesthesiol. 2014;14:112. (SCI 一作)

17. A changing of the Abbreviated Injury Scale that improves accuracy and simplifies scoring. Hong Kong J Emerg Med 2013;20(3):138-145. (SCI 共作)

18. The Tangent Function Transforms the Abbreviated Injury Scale That Both Improves Accuracy and Simplifies Scoring. Archives of Medical Science.2014 (SCI 通讯作者)

19. Diagnosis and microsurgery of symptomatic spontaneous spinal epidural hematoma. Ir J Med Sci. 2010 (SCI 通讯作者)

20. Effects of unilateral decompressive craniectomy on patients with unilateral acute post-traumatic brain swelling after severe traumatic brain injury. Critical Care 2009, 13:R185 doi:10.1186/cc8178 (SCI 一作)

21. Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy.J Crit Care. 2007;22(3):229-35. (SCI 一作)

22. Noninvasive selective brain cooling by head and neck cooling is protective in severe traumatic brain injury.J Clin Neurosci. 2006;13(10):995-1000. (SCI 一作)

23.Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary study. J Int Med Res. 2006;34(1):58-64. (SCI 通讯作者)

24. Thrombocytopenia after therapeutic hypothermia in severe traumatic brain injury. Chin J Traumatol,2006 9(4):238-41.(一作)

25. Therapeutic effect of mild hypothermia on severe traumatic head injury. Chin J Traumatol, 2005;8:27-3(一作)

26. Management of posttraumatic brain swelling based on clinical typing. Chin J Traumatol, . 2004 Jun;7(3):175-8. (一作)

27. 间充质干细胞移植治疗创伤性脑损伤的研究进展[J].浙江创伤外科, 2025, 30(11):2194-2197(通讯作者)

28. 儿童第四脑室肿瘤的临床特点和微创外科治疗[J]. 中华小儿外科杂志,2007,28(10):559-560. (一作)

29. 外伤后急性脑肿胀的临床分型与治疗[J]. 中华创伤杂志,2003,19(5):280-282.(一作)

30. 脑内单发转移瘤13例诊治分析[J]. 浙江医学,2009,31(8):1117-1118.(一作)

31. Rathke's囊肿的诊断和显微手术治疗[J]. 医师进修杂志,2005,28(8):37-39.(一作)

32. 脑胶质瘤分子病因及其靶向治疗的研究进展[J]. 全科医学临床与教育,2009,7(5):506-510(一作)

◆ 成果奖励

1.《选择性亚低温治疗大鼠脑外伤后Fas/Fas-L基因表达的影响》 获得浙江省医药卫生科技奖三等奖（2010年）

2.《院前亚低温治疗重型颅脑损伤的应用研究》   获得杭州市科技进步三等奖（2016年）

3.《亚低温治疗对重型颅骨损伤患者大脑半球Pbto2梯度的影响》   浙江省医药卫生科技奖三等奖（2015年）